兰州大学学报（医学版）2017，Vol.43Issue(6)：67-70,4.DOI:10.13885/j.issn.1000-2812.2017.06.014
乳腺癌新辅助化疗后病理完全缓解的临床因素分析
Analysis of clinical factors for pathological complete response after preoperative neoadjuvant chemotherapy for mammary cancer
李红生 1毛宏亮 1马永录 1张莉 2罗丽琼 1戴伟平 2高力英3
作者信息
- 1. 酒泉市人民医院肿瘤科,甘肃酒泉735000
- 2. 酒泉市人民医院病理科,甘肃酒泉735000
- 3. 甘肃省肿瘤医院放疗科,甘肃兰州730050
- 折叠
摘要
Abstract
Objective To evaluate the clinical factors associated with pathological complete response after preoperative neoadjuvant chemotherapy for mammary cancer.Methods We retrospectively analyzed the clinical data of 116 patients with mammary cancer who underwent neoadjuvant chemotherapy followed by surgery from January 2010 to December 2016.All patients received anthracene ring combined with taxane based chemotherapy drugs of 4-6 medications,and underwent radical surgery after treatment 2-4 week.The clinical factors associated with pCR or non-pCRwere analyzed by applying logistic regression.Results 20 patients (17.2％) achieved a pCR after neoadjuvant chemotherapy in all the 116 patients.The univariate analysis showed that T stage,N stage,histological grading of mammary cancer,molecular subtyping of mammary cancer,expression level of Ki-67 before the treatment were associated with pCR or non-pCR after neoadjuvant chemotherapy for mammary cancer.The multi-variate analysis revealed that T stage,histological grading of mammary cancer and expression level of Ki-67 before the treatment were predictive factors for pCR or nonpCR after neoadjuvant chemotherapy for mammary cancer.Conclusion Early T stage,non-Luminal and high expression level of Ki-67 before treatment might be associated with pCR after neoadjuvant chemotherapy for mammary cancer.关键词
乳腺癌/新辅助化疗/病理完全缓解Key words
mammary cancer/neoadjuvant chemotherapy/pathological complete response分类
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李红生,毛宏亮,马永录,张莉,罗丽琼,戴伟平,高力英..乳腺癌新辅助化疗后病理完全缓解的临床因素分析[J].兰州大学学报（医学版）,2017,43(6):67-70,4.
