摘要
Abstract
Objective:To investigate the expression of insulin-like growth factor( IGF) in oral squamous cell carcino-ma and its clinical significance. Methods:One hundred and thirty-four cases of oral squamous cell carcinoma patients in our hospital as the research object,the expression of insulin-like growth factor( IGFs) in oral squamous cell carcinoma tissues,ab-normal paracancerous tissues and normal paracancerous tissues was determined by LSAB. The relationship of the expression of IGFs scores and the baseline data( age and gender) ,pathological grade,tumor differentiation index( postoperative TNM stag-ing and lymph node metastasis)and prognosis index(one-year survival)were analysed. Results:In different tissues(normal cancer center,abnormal cancer tissues and adjacent tissues),different tumor differentiation grade and postoperative TNM staging,lymph node metastasis and without metastasis,insulin-like growth factor expression was statistically significant( P<0. 05). Cancer tissue,tissue adjacent to cancer center abnormal insulin high and low expression and high expression of growth factor scores and low expression scores in different tumor differentiation grade and different postoperative TNM staging,lymph node metastasis and without metastasis and 1 year survival or death,were significant statistical significance(P<0. 05). Con-clusion:Insulin like growth factor abundance in cancer tissues and center of oral squamous cell carcinoma,immune function in tumor cell regulation,and its expression level is correlated with pathological parameters and prognosis.关键词
口腔鳞状细胞癌/胰岛素样生长因子/表达/临床意义Key words
Oral squamous cell carcinoma/Insulin-like growth factor/Expression/Clinical significance分类
医药卫生
