摘要
Abstract
Objective:To investigate the prognostic role of EGLN3 in patients with oral squamous cell carcinoma. Methods:The oral squamous cell carcinoma( OSCC) gene expression datasets GSE42743 was reanalyzed to characterize the expression of EGLN3 gene between oral cancer patients and adjacent normal tissue,and the correlations between EGLN3 ex-pression and the T staging,CN staging,PN staging,AJCC staging,overall survival and OSCC specific survival of oral cancer patients. Gene set enrichment analysis was applied to investigate the exact mechanisms regarding the expression of EGLN3 and the proliferation of OSCC cells. Results:The level of EGLN3 expression was significantly higher in OSCC patients than that in normal controls(P<0. 0001). OSCC patients with lower expression of EGLN3 were associated with better T staging, PN staging,CN staging,AJCC staging,overall survival,and OSCC specific survival compared with EGLN3 higher expression cohort. The result of GSEA indicated that EGLN3 might promote the proliferation of OSCC cells biological processes involving mTORC1,E2 F,MYC,and NOTCH signaling,protein secretion,mitotic spindle,G2M checkpoint,glycolysis,cholesterol home-ostasis and unfold protein response. Conclusion:EGLN3 might be an independent risk factor for OSCC patients.关键词
口腔鳞状细胞癌/EGLN3基因/临床预后Key words
Oral squamous cell carcinoma/EGLN3/Clinical prognosis分类
医药卫生
