临床误诊误治2018，Vol.31Issue(1)：73-77,5.DOI:10.3969/j.issn.1002-3429.2018.01.027
饮酒及ADH2、ALDH2基因多态性与OSAHS的关系
The Effects of Alcohol Ingestion on OSAHS and Relationship between ADH2/ALDH2 Genetic Polymorphisms and Obstructive Sleep Apnea Syndrome
摘要
Abstract
Objective To evaluate the effects of alcohol ingestion on obstructive sleep apnea hypopnea syndrome (OSAHS) and the relationship between functional ADH2 Arg47His and ALDH2 Glu487Lys polymorphisms and OSAHS. Methods The data were collected from a chart review of patients with sleep snoring, a1l patients who have been tested for PSG in our center from February 2014 to February 2017 were surveyed. A total of 321 patients were excluded, the recruited subjects were divided into OSAHS (n=208) and non-OSAHS (n=113) groups. Information about drinking condition was collected. The polymorphisms of ADH2 Arg47His and ALDH2 Glu487Lys were detected by PCR-LDR methods. Unconditional logistic regression analysis was used to adjust the potential confounding factors and to assess the independent effect of each contributing factor on the presence of OSAHS. Results BMI, neck circumference, abdominal circumference and snore age were statistically significant difference respectively between OSAHS group and non-OSAHS group (P<0. 05 or P<0. 01). The frequency of ADH2 genotype AA/( A/G+G/G) and ALDH2 genotype GG/( G/A+A/A) in OSAHS group had no statistical differences comparing with the control group (χ2 =1. 23, χ2 =2. 37, P>0. 05). Compared with ADH2 genotype A/A and ALDH2 genotype G/G, other genotypes did not increase the risk of developing the OSAHS. Conclusion Drinking is a risk factor for OSAHS, ADH2 Arg47His and ALDH2 Glu487Lys genetic polymorphisms had no association with OSAHS and the se-verity of OSAHS.关键词
睡眠呼吸暂停,阻塞性/饮酒/ADH2/ALDH2/基因多态性Key words
Sleep apnea/obstructive/Alcohol drinking/ADH2/ALDH2/Genetic polymorphisms分类
医药卫生引用本文复制引用
高蔚,肖永龙,施斌,翁婷..饮酒及ADH2、ALDH2基因多态性与OSAHS的关系[J].临床误诊误治,2018,31(1):73-77,5.基金项目
宿迁市科技支撑计划项目(S201518) （S201518）
