青岛大学学报（自然科学版）2017，Vol.30Issue(4)：36-41,6.DOI:10.3969/j.issn.1006-1037.2017.11.08
一种席夫碱镉(Ⅱ)配合物对人前列腺癌LN-CaP细胞增殖抑制及凋亡诱导作用研究
The Effect of Proliferation Inhibition and Apoptosis Induction of One Schiff Based Cadmium Complex on LN-CaP Human Prostate Cancer Cells
摘要
Abstract
The proteasome is a new target of design and development of anticancer drugs.5-Bromo-2-thiophenecarbaldehyde-L-tryptophan Schiff based on cadmium complex is an effective proteasome inhibitor,but since this cadmium complex can hardly enter human breast cancer cells freely,its therapeutic use as a potent apoptosis inducer on human breast cancer cell is nullified.It is showed that the cadmium complex can get into the LN-CaP human prostate cancer cells with a certain degree of selectivity.5-Bromo-2-thiophenecarbaldehyde-L-tryptophan Schiff base cadmium complex can inhibit chymotrypsin-like activity of the LN-CaP human prostate cancer cells,inducing apoptosis in cultured LN-CaP human prostate cancer cells strongly.关键词
5-溴噻吩-2-甲醛/L-色氨酸/席夫碱镉配合物/蛋白酶体抑制剂/抗肿瘤Key words
5-bromo-2-thiophenecarbaldehyde/L-tryptophan/schiff base cadmium complex/proteasome inhibitor/anticancer分类
生物科学引用本文复制引用
马燕飞,张霞,张栋梅,王新萍,李昉,张楠..一种席夫碱镉(Ⅱ)配合物对人前列腺癌LN-CaP细胞增殖抑制及凋亡诱导作用研究[J].青岛大学学报（自然科学版）,2017,30(4):36-41,6.基金项目
国家自然科学基金(批准号:21371161)资助. （批准号:21371161）
