人工晶体学报2017，Vol.46Issue(12)：2478-2484,7.
超顺磁Fe3O4纳米粒子的制备及弛豫性能
Synthesis of Superparamagnetic Fe3 O4 Nanoparticles and Its Relaxation Properties
摘要
Abstract
Superparamagnetic Fe 3 O4 nanoparticles with polyacylic acid coating and high hydrophilicity were synthesized by simple coprecipitation method .The influence of Fe2 +:Fe3+( mole ratio) on the nanoparticle size was investigated . The crystal phase of Fe 3 O4 was confirmed by high resolution transmission electron microscopy and X-ray diffraction analysis .Infrared spectrum and thermogravimetric analysis indicate that poly acrylic acid is successfully coated onto the surface of the nanoparticles .The size of particles and their distribution is obtained from TEM .Average crystal size is infered from X-ray diffraction analysis.The average particles size from TEM and XRD are 7.2 nm, 6.7 nm, 8.3 nm and 9. 1 nm, 8.2 nm, 9.1 nm, respectively, corresponding to Fe2+:Fe3+ =1:1.5, 1:1.75 and 1:2. Dynamic laser scatter analysis reveals that it has some larger particles . The nanoparticles show superparamagnetic properties under room temperature .Relaxation analysis indicates that the sample 1:1. 5 is more suitable for T1 contrast agents and 1:1.75 and 1:2 are for T2 ones.It provides a new way for the optimization of the MR contrast agents .关键词
Fe3O4纳米粒子/共沉淀/超顺磁/磁共振造影剂/弛豫性能Key words
magnetite nanoparticle/coprecipitation/superparamagnetic/magnetic resonance imaging contrast agent/relaxation property分类
通用工业技术引用本文复制引用
肖旺钏,纪孝峰,郑英,范彩霞,赖文忠,赵炎,罗菊香,郑可利..超顺磁Fe3O4纳米粒子的制备及弛豫性能[J].人工晶体学报,2017,46(12):2478-2484,7.基金项目
福建省科技厅引导性项目(2015Y0077) （2015Y0077）
福建省卫生教育联合攻关计划项目(WKJ-FJ-36) （WKJ-FJ-36）
福建教育厅科技项目(JA12299) （JA12299）
福建省自然科学基金(2015J01567) （2015J01567）
汕头大学医学院博士后基金 （）
韶关市科学计划项目(卫)(2013-CX/K191) （卫）
