生命科学研究2017，Vol.21Issue(6)：534-541,8.DOI:10.16605/j.cnki.1007-7847.2017.06.012
中枢神经系统少突胶质细胞前体细胞产生的研究进展
Progresses on the Generation of Oligodendrocyte Progenitor Cells in Central Nervous System
摘要
Abstract
Myelin sheath formed by oligodendrocytes (OLs) wraps axons in the central nervous system (CNS),ensures rapid conduction of nerve impulses and metabolically supports axons.Abnormal development of oligodendrocytes causes severe neurological diseases,such as leukodystrophy and multiple sclerosis (MS).The generation of oligodendrocyte progenitor cells (OPCs) from neural progenitor cells (NPCs) is regulated precisely by multiple intracellular and extracellular factors,and belongs to the major contents of neurobiological researches.Based on substantial researches in recent years,the progresses on OPC generation are summarized here.关键词
神经前体细胞(NPCs)/少突胶质细胞前体细胞(OPCs)/信号通路/转录调控/神经发育/再生Key words
neural progenitor cells (NPCs)/oligodendrocyte progenitor cells (OPCs)/signal pathway/transcriptional regulation/neural development/regeneration分类
生物科学引用本文复制引用
易敏,杜君卿,黄浩..中枢神经系统少突胶质细胞前体细胞产生的研究进展[J].生命科学研究,2017,21(6):534-541,8.基金项目
国家自然科学基金资助项目(31572224) （31572224）
浙江省自然科学基金资助项目(LY15C090008) （LY15C090008）
