生命科学研究2017，Vol.21Issue(6)：542-546,5.DOI:10.16605/j.cnki.1007-7847.2017.06.013
寡肽转运蛋白(PepT1)的研究进展
Recent Advances of Oligopeptide Transporter 1 (PepT1)
韩迪 1韩兴鹏 1郑健 1李树威 1于涛1
作者信息
- 1. 东北林业大学盐碱地生物资源与环境研究中心/东北盐碱植被恢复与重建教育部重点实验室,中国黑龙江哈尔滨150040
- 折叠
摘要
Abstract
O1igopeptide transporter 1 (PepT1),a proton-dependent transporter,is widely distributed in intestinal epithelial cells.PepT1 is responsible for the transport of dipeptides,tripeptides and their analogues,all of which originate from the digestion of proteins.The investigation on PepT1 is of great advantage to improve the bioavailability of drugs,especially those for the treatment of cancer.Here,the crystal structure,prodrugs,substrates,interaction proteins of PepT1,as well as its response to diseases were reviewed.关键词
寡肽转运蛋白1 (PepT1)/晶体结构/靶向前药/转运底物/蛋白质互作/应答机制Key words
oligopeptide transporter 1 (PepT1)/crystal structure/prodrugs/substrates/interaction protein/response分类
生物科学引用本文复制引用
韩迪,韩兴鹏,郑健,李树威,于涛..寡肽转运蛋白(PepT1)的研究进展[J].生命科学研究,2017,21(6):542-546,5.
