生命科学研究2017，Vol.21Issue(6)：552-557,6.DOI:10.16605/j.cnki.1007-7847.2017.06.015
分子马达KIF1A的研究进展
Research Progresses on Molecular Motor KIF1A
摘要
Abstract
Kinesin family member 1A (KIF1A) is a plus-end kinesin-3 family motor protein that moves along microtubule filaments and is powered by the energy derived from ATP hydrolysis.It is an important transporter of synaptic vesicle precursors along microtubule bundles to the axon terminal.Mutations in the motor domain of KIF1A may cause a variety of nerve-related diseases and defects.Here,the recent research advances of KIF1A related life processes and diseases are summarized and the key intermediate structures of KIF1A ATPase reaction cycle are presented.Based on this structural information,the movement form,the mechanism of nucleotide exchange and the movement mechanism of KIF1A are described.In addition,some open questions and future prospect of KIF1A research are also discussed to offer new sights for KIF1A related research.关键词
分子马达/驱动蛋白KIF1A/三磷酸腺苷(ATP)/微管/核苷酸结合位点/运动机理Key words
molecule motor/kinesin KIF1A/adenosine triphosphate (ATP)/microtubule/nucleotide binding sites/movement mechanism分类
生物科学引用本文复制引用
黄艳宾,李洁,刘秀红,纪青..分子马达KIF1A的研究进展[J].生命科学研究,2017,21(6):552-557,6.基金项目
国家自然科学基金资助项目(10975044,11505045) （10975044,11505045）
河北省自然科学基金资助项目(A2015402035) （A2015402035）
邯郸市科学技术研究与发展计划项目(1221107079-6,1121103183) （1221107079-6,1121103183）
邯郸学院研究课题(15219,14202) （15219,14202）
