生物骨科材料与临床研究2017，Vol.14Issue(6)：1-6,后插1,7.DOI:10.3969/j.issn.1672-5972.2017.06.001
载药硼酸盐骨水泥的制备及其体外生物活性和抗菌性能的研究
The preparation, bioactivity and antibiotic property of drug loading borate bone cement
摘要
Abstract
Objective The objective of this study was to develop a borate bone cement (BBC) that could serve as a carrier for delivering Gentamycin Sulfate (GS) and evaluate the capacity of antibiotic in vitro.Methods A local drug delivery system,using novel BBC as carrier for GS,was prepared.The effect ofdrug loading on the injectability,initial setting time of the injectable BBC was tested.The bioactivity,biodegradation and loading/release capacity of the BBC was evaluated by immersing the pre-set BBC samples in phosphate buffered saline,PBS.The in vitro antibiotic property was test by the inhibition zone of the E.coli and S.aureus cultured on the LB agar plates.Results The BBC loaded with GS can be almost completed injected by syringe,and had a proper initial setting time of about 6 min.When immersed inPBS,sustained release ofGS occurred over 26days,while the borate bioactive glass in BBC converted continuously to hydroxyapatite (HA).After loading with GS,the BBC can inhibit the growth of E.coli and S.aureus effectively.Conclusion The results suggest that,GS loaded BBC,had an excellent injectability,proper in-situ self-curing time,long and sustained drug release and the ability to inhibit bacterium growth.关键词
可注射/硼酸盐生物玻璃/骨水泥/药物载体/抗菌性能Key words
Injectable/Borate bioactive glass/Bone cement/Drug delivery/Anti bacterial property分类
医药卫生引用本文复制引用
崔旭,黄程程,张朦,杨鸿生,阮长顺,黄文旵,潘浩波..载药硼酸盐骨水泥的制备及其体外生物活性和抗菌性能的研究[J].生物骨科材料与临床研究,2017,14(6):1-6,后插1,7.基金项目
广东省自然科学基金-博士启动纵向协同项目(锶硼协同生物玻璃骨水泥用于骨质疏松性脊柱椎体骨折的修复及其机制),编号(2017A030310318) （锶硼协同生物玻璃骨水泥用于骨质疏松性脊柱椎体骨折的修复及其机制）
深圳市科技创新委员会技术攻关项目(骨质疏松性椎体骨折修复新技术研发),编号:(JSGG20150331154931068) （骨质疏松性椎体骨折修复新技术研发）
深圳市科技创新委员会技术开发项目(海洋源生物活性骨水泥在脊柱压缩性骨折中应用的临床前研究),编号(CXZZ20150401152251209) （海洋源生物活性骨水泥在脊柱压缩性骨折中应用的临床前研究）
深圳市大鹏新区产业发展专项资金-科技研发项目(海洋源生物活性骨水泥的前期研究),编号(KY20150110)等. （海洋源生物活性骨水泥的前期研究）
