生物骨科材料与临床研究2017，Vol.14Issue(6)：7-10,后插2,5.DOI:10.3969/j.issn.1672-5972.2017.06.002
负载抗菌药物骨水泥的药物释放实验研究
The drug release characteristics of antibiotic-loaded polymethyl methacrylate cements
吕静 1叶盛英 2王昊 3郝建华 3满淑丽 4谢宝钢3
作者信息
- 1. 天津解放军第254医院肾内科,天津300142
- 2. 天津解放军第254医院药剂科,天津300142
- 3. 天津解放军第254医院骨科,天津300142
- 4. 天津科技大学生物工程学院,天津300457
- 折叠
摘要
Abstract
Objective The effects of the drug concentration,release period,the residue concentration,and releasing time that under the minimal inhibitory concentration from polymethyl methacrylate (PMMA) cement will be studied,in order to lay down a theoretical basis for rational use of antibacterial drugs.Methods Imipenem or vancomycin loaded in the PMMA cement samples was eluted in vitro.High performance liquid chromatography (HPLC) was used to quantitatively determine the releasing profile and residue of imipenem or vancomycin in the antibiotic-loaded PMMA samples.Results ① Antibiotics rapidly released from the PMMA samples on the first day,and slowly released at a low concentrationafterwards;② Only 15％ ofvancomycin and 25％ ofimipenem were separately released from the antibiotic-loaded PMMA samples after elution for seven weeks.Therefore,there were a large amount of antibiotics remained in the PMMA;③ The drug releasing concentration from vancomycin-loaded PMMA was lower than the minimal inhibitory concentration after one week,while that from imipenem-loaded PMMA was lower than the minimal inhibitory concentration after seven weeks.Conclusion The drug releasing concentration from antibiotic-loaded PMMA samples was lower than the minimum bacteriostatic concentration,due to a large amount of residues in the PMMA,which likely results in antibiotics resistance for bacteria.关键词
骨水泥/药物控释/抗菌药物残留Key words
Polymethyl methacrylate cement/Drug controlled release/Antibiotic residues分类
医药卫生引用本文复制引用
吕静,叶盛英,王昊,郝建华,满淑丽,谢宝钢..负载抗菌药物骨水泥的药物释放实验研究[J].生物骨科材料与临床研究,2017,14(6):7-10,后插2,5.
