生物骨科材料与临床研究2017，Vol.14Issue(6)：11-13,21,4.DOI:10.3969/j.issn.1672-5972.2017.06.003
补骨脂素对骨质疏松小鼠骨代谢指标和生物力学的影响
A study on the influence of psoralen on bone metabolism and biomechanics in ovariectomized mice
黄奎 1邹季2
作者信息
- 1. 湖北中医药大学,湖北武汉430065
- 2. 长江大学附属第一医院骨科,湖北荆州434000
- 折叠
摘要
Abstract
Objective To investigate the effect of psoralen on bone metabolism and biomechanics in ovariectomized (OVX) mice model.Methods A total of 40 mice were randomly divided into sham operation group (SHAM+NS),model group (OVX+NS),estradiol group (OVX+ estradiol) and psoralen group (OVX+ psoralen),with 10 mouse in each group.After the medication for 6 weeks,blood was collected to assay serum alkaline phosphatase (ALP),Cterminal cross-linking telopeptides of type Ⅰ collagen (CTX-1) and estrogen.Biomechanics was studied using three-point bending test.Results Compared with the model group,the levels of ALP in psoralen group was increased but not significant,the level of CTX-I were significantly decreased in estradiol group and psoralen group.Compared with the model group,level of estrogen was obviously increased in estradiol group but maintained a low level in psoralen group.Compared with the model group,the maximum load,maximum stress and flexure modulus were significantly increased.Conclusion Psoralen as a natural phytoestrogen promotes the bone metabolism and biomechanics in ovariectomized mice.关键词
补骨脂素/卵巢切除小鼠/骨代谢/生物力学Key words
Psoralen/Ovariectomized mice/Bone metabolism/Biomechanics分类
医药卫生引用本文复制引用
黄奎,邹季..补骨脂素对骨质疏松小鼠骨代谢指标和生物力学的影响[J].生物骨科材料与临床研究,2017,14(6):11-13,21,4.
