生殖医学杂志2018，Vol.27Issue(1)：16-20,5.DOI:10.3969/j.issn.1004-3845.2018.01.004
卵母细胞滑面内质网聚集对MII卵母细胞有效胚胎形成率的影响
Effect of oocytes with smooth endoplasmic reticulum aggregation on oocyte-to-embryo rate
摘要
Abstract
Objective:To study the effect of smooth endoplasmic reticulum aggregation (SERa)in oocytes on oocyte-to-embryo rate.Methods:The data of 250 cycles of ICSI-treated patients from January 2013 to December 2014 were retrospectively analyzed.According to whether oocytes had SERa,the cycles were divided into two groups:at least one oocyte with SERa positive in SERa+ group(group A,50 cycle)and all oocytes without SERa in SERa-group(group B,200 cycle).The fertilization rate,abnormal fertilization rate,cleavage rate,available embryos rate and oocyte-to-embryo rate were compared between the two groups.Results:The significantly lower cleavage rate,available embryos rate,oocyte-to-embryo rate and significantly higher multiple pronucleus fertilization rate were observed in the SERa+ cycles as compared to SERa-cycles(P＜0.05).SERa+ cycles had significantly lower cleavage rate,available embryos rate & oocyte-to-embryo rate,and significantly higher multiple pronucleus fertilization rate (P ＜ 0.05) compared with SERa oocyes.Among SERa+ cycles,SERa+ oocytes had higher multiple pronucleus fertilization rate compared to SERa oocytes(P＜0.05),while there was no significant difference in cleavage rate,available embryos rate and oocyte-to-embryo rate between SERa+ oocytes and SERa-oocytes(P＞0.05).Conclusions:Oocyte cytoplasmic smooth endoplasmic reticulum aggregation increases abnormal fertilization rate and reduces oocyt-to-embryo rate.关键词
卵母细胞/ICSI/滑面内质网/卵母细胞利用率Key words
Oocytes/ICSI/Smooth endoplasmic reticulum/Oocyte-to-embryo rate引用本文复制引用
潘家坪,阮井玲,黄媚媛,王羽,梁珊珊,滕晓明,吴海霞..卵母细胞滑面内质网聚集对MII卵母细胞有效胚胎形成率的影响[J].生殖医学杂志,2018,27(1):16-20,5.基金项目
上海市卫计委课题(201440005) （201440005）
卫生计生委公益项目(201402004) （201402004）
