外科理论与实践2017，Vol.22Issue(6)：509-514,6.DOI:10.16139/j.1007-9610.2017.06.012
肝内胆管癌手术切除预后的相关因素研究
Surgical resection of intrahepatic cholangiocarcinoma: analysis of prognostic factors
摘要
Abstract
Objective To analyze the prognostic factors of surgical resection of intralhepatic cholangiocarcinoma and the clinical effect of radical resection.Methods The patients undergoing resection for intrahepatic cholangiocarcinoma in our hospital from October 2004 to December 2016 were analyzed retrospectively with the prognosis factors.Results A total of 163 cases (86.7％) from 188 cases with intrahepatic cholangiocarcinoma were treated by resection.The 1-,3-and 5-year survival rate of 163 cases after resection was 64.5％,36.2％ and 23.6％ respectively.The median overall survival time was 26 months.There were 37 (22.7％) cases with postoperative complications.Two cases died of hepatic failure and 1 case septic shock with mortality (1.84％).Multivariate analysis identified independent poor prognostic factors including positive surgical margin(HR=5.95,P＜0.001),hepatolithiasis (HR=2.50,P=0.03),lymph node metastasis(HR=3.34,P=0.006),TNM stage Ⅲ-Ⅳ (HR=3.11,P=0.048) and lower tumor differentiation (HR=2.37,P=0.021).Conclusions Surgical margin,hepatolithiasis,lymph node metastasis,TNM staging and tumor differentiation were related with prognosis of the patients with intrahepatic cholangiocarcinoma.Surgical treatment is an important strategy and radical resection offers the opportunity of long-term survival.关键词
肝内胆管癌/外科治疗/预后/根治性切除Key words
Intrahepatic cholangiocarcinoma/Surgical treatment/Prognosis/Radical resection分类
医药卫生引用本文复制引用
焦臣宇,张慧,王科,武正山,吴晓峰,韩晟,王东,季顾惟,李相成..肝内胆管癌手术切除预后的相关因素研究[J].外科理论与实践,2017,22(6):509-514,6.基金项目
国家自然科学基金(81670570) （81670570）
江苏省重点病种规范化诊疗项目(BE2016789) （BE2016789）
