中国病理生理杂志2018，Vol.34Issue(1)：163-167,5.DOI:10.3969/j.issn.1000-4718.2018.01.028
人参皂苷Rh1对哮喘模型小鼠炎症因子表达的抑制作用
Effects of ginsenoside Rh1 on expression of inflammatory factors in mouse asthma model
摘要
Abstract
AIM:To observe the effects of ginsenoside Rh 1 on the levels of inflammatory factors in serum and bronchoalveolar lavage fluid(BALF),and the pathological changes of the lung tissues in an experimentally induced mouse asthma model.METHODS:Male BALB/c mice(n=40)were divided into 4 groups:normal control group,asthma mo-del group,and low-dose(40 mg· kg-1 · d-1 )and high-dose(80 mg· kg-1 · d-1 )ginsenoside Rh1 groups.The bron-chial asthma mouse model was established by the method of ovalbumin induction and excitation ,and during the excitation period,the mice were daily treated with ginsenoside Rh 1 for 2 weeks.At 24 h after the final dose of ginsenoside Rh 1,the mice were sacrificed.The number of eosinophils(EOS)and the concentrations of interleukin(IL)-4,IL-5 and interferon(IFN)-γin BALF were determined.The levels of IgG and IgE in serum were measured ,and the expression of transforming growth factor(TGF)-β1 and the pathological changes in lung tissues were evaluated.RESULTS:Ginsenoside Rh1 inhibi-ted the increases in the number of EOS and the concentrations of IL-4,IL-5,IFN-γand IgE,reversed the increased ex-pression of TGF-β1,and improved the pathological changes of the lung tissues in asthmatic mice.CONCLUSION:Gin-senoside Rh1 improves the immuno-inflammatory profile and pathological changes in the experimentally induced mouse asth -ma model,implying its potential therapeutic effect on asthma.关键词
支气管哮喘/人参皂苷Rh1/炎症因子/肺组织Key words
Bronchial asthma/Ginsenoside Rh1/Inflammatory factors/Lung tissue分类
医药卫生引用本文复制引用
张春晶,李淑艳,赵容杰,赵正林..人参皂苷Rh1对哮喘模型小鼠炎症因子表达的抑制作用[J].中国病理生理杂志,2018,34(1):163-167,5.基金项目
齐齐哈尔医学院博士科研基金资助项目(No.QY2016B-36) （No.QY2016B-36）
