中国动脉硬化杂志2017，Vol.25Issue(12)：1231-1236,6.
代谢综合征患者白细胞介素6水平与HDL亚类分布的相关性分析
Correlation coefficients between the distribution of HDL subclasses and the plasma interleukine-6 in patients with metabolic syndrome
摘要
Abstract
Aim To investigate the association between high density lipoprotein (HDL) subclasses and IL-6 concentration in patients with metabolic syndrome (MS).Methods The MS subjects (n =135) and healthy controls (n =77) were selected.The levels of IL-6 were determined by enzyme-linked immunosorbent assay (ELISA) kits.According to the levels of plasma IL-6,the MS subjects were divided into three groups:low IL-6 group (IL-6≤ 66.76 ng/L),middle IL-6 group (66.76 ng/L ＜ IL-6 ＜ 113.84 ng/L),and high IL-6 group (IL-6 ≥ 113.84 ng/L).The contents of plasma HDL subclasses were determined by Two Dimensional Gelelectrophoresis-Immunodetection.The levels of plasma lipids and the apolipoproteins in the MS subjects and healthy controls were detected by automated biochemical analyzer.It analyzed the impact of different genders on IL-6,lipids,apolipoproteins,HDL subclasses in the subjects and correlation coefficients between the distribution of HDL subclasses and IL-6 in patients with MS.Results Compared with control,the levels of IL-6,preβ1-HDL,HDL3b,HDL3c,plasma total cholesterol (TC),triglyceride (TG),low density lipoprotein cholesterol (LDLC),LDLC/HDLC and ApoB100/ApoAI were significantly increased in MS subjects (P＜0.05 or P＜0.01),while HDL2a,HDL2b,preβ2-HDL,apolipoprotein AI (ApoAI) and high density lipoprotein cholesterol (HDLC) were significantly decreased in MS subjects (P＜0.05 or P＜0.01).Compared with the control group of the same sex,the relative content of HDL subclass of male or female in MS group was significantly different (P＜0.05 or P＜0.01).Compared with the same group of males,the level of lipids,apolipoproteins in control group and MS group were no statistical significance (P＞0.05).The correlation analysis showed that IL-6 was positively correlated with the level of preβ1-HDL and HDL3b and negatively correlated with the level of HDL2b.Conclusion The plasma IL-6 levels were increased in MS patients,and the particle size of HDL showed a shift toward smaller size.The increasing of IL-6 may be related to HDL subclasses distribution abnormality and dyslipidemia.关键词
代谢综合征/HDL亚类/白细胞介素6/双向电泳-免疫印记法Key words
Metabolic syndrome/High density lipoprotein subclasses/Interleukine-6/Two dimensional gelelectrophoresis-immunodetection分类
医药卫生引用本文复制引用
丁新新,仇梦霞,肖梨花,丁岚,张彩平,张敏,欧淳,田英,龙石银..代谢综合征患者白细胞介素6水平与HDL亚类分布的相关性分析[J].中国动脉硬化杂志,2017,25(12):1231-1236,6.基金项目
国家自然科学基金资助项目(81600291) （81600291）
湖南省研究生科研创新项目(CX2016B474) （CX2016B474）
湖南省教育厅项目(15B211,15C1217) （15B211,15C1217）
湖南省高层次卫生人才“225”工程项目基金、湖南省大学生研究性学习和创新性实验计划项目(2015-230) （2015-230）
衡阳市科技局项目(2015KJ15) （2015KJ15）
南华大学科技创新团队基金、南华大学留学回国人员启动基金(2013XQD52) （2013XQD52）
