中国动脉硬化杂志2017，Vol.25Issue(12)：1237-1241,5.
红细胞分布宽度预测2型糖尿病患者支架内再狭窄
Relationship between red blood cell distribution width and in stent restenosis in type 2 diabetes patients
摘要
Abstract
Aim To explore the predictive value of red blood cell distribution width (RDW) for in-stent restenosis (ISR) after coronary stenting with drug-eluting stent (DES) in patients of type 2 diabetes.Methods The study retrospectively searched data at Tianjin Nankai Hospital for 582 unstable angina pectoris patients with type 2 diabetes who underwent PCI from January 2012 to December 2016.Among these patients,292 patients with coronary DES implantation were enrolled in this study.The ISR was analyzed by coronary angiography analysis at a mean follow-up of eight months.According to whether ISR was detected,type 2 diabetes patients were divided into two groups:the ISR group (n =45) and the non-ISR group (n =247).Patients' clinical and demographic characteristics were recorded including age,gender,smoking,anamnesis,RDW,C-reactive protein (CRP),cardiac ultrasound,coronary angiography,and so on.Results The body mass index (BMI) levels were higher in the ISR group than that in the non-ISR group (P＜0.05).Patients with ISR had higher smoking rates (P＜0.05).In addition,patients in the ISR group had significantly higher RDW levels compared with patients in the non-ISR group both at admission and at follow-up (P＜0.01,respectively).Furthermore,the ISR group had significantly longer stent length and lower stent diameter compared with the non-ISR group (P＜0.01,respectively).In an univariate model using RDW as a continuous variable,there was a significantly positive association between RDW levels and the incidence of ISR (P＜0.01).Further multivariate logistic regression analysis revealed that BMI,smoking,RDW,CRP,stent length,and stent diameter were associated independently with ISR.Conclusion Elevated RDW has predictive value for ISR occurrence in type 2 diabetes patients with coronary DES implantation,which indicates that a chronic inflammatory response might be involved in the pathogenesis of ISR.关键词
红细胞分布宽度/2型糖尿病/支架内再狭窄/经皮冠状动脉介入治疗Key words
Red blood cell distribution width/Type 2 diabetes/In-stent restenosis/Percutaneous coronary intervention分类
医药卫生引用本文复制引用
赵凯,李永健,高晟,王慧..红细胞分布宽度预测2型糖尿病患者支架内再狭窄[J].中国动脉硬化杂志,2017,25(12):1237-1241,5.基金项目
国家自然科学基金青年项目(81503409) （81503409）
