摘要
Abstract
Aim To explore the relationship between serum monocyte chemoattractant protein-1 (MCP-1) level and MCP-1 2518G/A polymorphism in patients with acute myocardial infarction (AMI) in Chinese Han population in Lianshui County of Northern Jiangsu.Methods Serum MCP-1 level was measured by ELISA,and the MCP-1 2518 G/A polymorphism was genotyped by PCR-RFLP in 94 patients with AMI and 73 control subjects.Results Serum MCP-1 level(expressed in M/IQR) was significantly higher in AMI group (186.24/285.15 ng/L) than that in control group (100.71/134.02 ng/L,P =0.001).Multiple linear regression analysis revealed that the serum MCP-1 level was negatively correlated with male,positively correlated with smoking,history of diabetes mellitus and hypertension,but unrelated with old age and dislipidemia in AMI group.After adjustment for hypertension,diabetes mellitus,age,gender,dislipidemia,and smoking,serum MCP-1 level of higher than 75％ quantile was positively correlated with the risk of AMI (OR=2.764,95％CI was 1.061～7.204,P=0.037).There was no significant difference in genotype distribution and allele frequency of MCP-1 2518G/A between AMI group and control group (P＞0.05).There was no significant difference in serum MCP-1 level among the genotypes of the control group and the AMI group (P＞0.05).Conclusion Serum MCP-1 level was significantly higher in AMI group than that in control group in Chinese Han population in Lianshui County of Northern Jiangsu.Serum MCP-1 level was affected by sex,hypertension,diabetes,and smoking,but serum MCPllevel of higher than 75％ quantile was an independent predictor of AMI.MCP-1 2518G/A polymorphism did not increase the susceptibility of AMI,nor affect the serum level of MCP-1.关键词
单核细胞趋化蛋白1/急性心肌梗死/基因多态性Key words
Monocyte chemoattractant protein-1/Acute myocardial infarction/Gene polymorphism分类
医药卫生
