王春花 1孙蕊 2王志锐 2巨韩芳 2穆成 2赵慧 2谢彤2
作者信息
- 1. 300070 天津医科大学公共卫生学院
- 2. 天津市结核病控制中心结核参比室
- 折叠
摘要
Abstract
The aim of this study was to analyze the infection tendency and drug resistance of nontuberculous mycobacteria (NTM) isolated from 2011 to 2015 in Tianjin.From January 1,2011 to December 31,2015,all the sputum culture-positive strains from new tuberculous (TB) patients in the Tianjin Center for Tuberculosis Control and the 15 TB control institutions in municipality and country (or designated hospitals) and the prison hospitals were collected.Para-nitro benzoic acid (PNB) and Thiophene-2-carboxylic acid hydrazide (TCH) were used to identify the species.Ratio drug sensitive test was used to analysis the drug resistant rate of the NTM stains.Six drugswere tested,including Streptomycin (Sm),isoniazid (INH),rifampicin (RFP),ethambutol (EMB),ofloxacin(Ofx),and kanamycin (Km).Results showed that in the 3972 isolated strains,there were 3899 (98.16％) strainsof MTB and 73 (1.84％) strains of NTM.The overall resistance rate of NTM was 98.63％ (72/73).The drug re-sistance rate of NTM to INH,Sm,RFP,EMB,Ofx,and Km were 94.52％ (69/73),80.82％ (59/73),56.16％(41/73),64.38％ (47/73),58.90％ (43/73),and 73.97％ (54/73).There were 21 strains resistant to all of thesix drugs,and 17 strains resistant to five drugs,accounting for 52.06％ (38/73) in all NTM.Drug resistance spectrum analysis indicated that the most common drug-resistant strains were resistant to all of the six drugs (28.77％(21/73)),followed by Sm+ IN+Km (10.96％ (8/73)) and Sm+ INH+RFP+EMB+Km (9.59％ (7/73)).INH was included in all above drug-resistant combination.The rate of EMB resistance decreased from 93.33％(14/15) in 2011 to 42.86％ (9/21) in 2015 (x2 =13.32,P=0.001),while the resistance rate of other five drugswere not significantly changed from 2011 to 2015.关键词
分枝杆菌,非典型性/抗结核药/抗药性,细菌Key words
Mycobacteria, atypical/Antitubercular agents/Drug-resistance, bacterial
