中国实用内科杂志2017，Vol.37Issue(12)：1074-1078,5.DOI:10.19538/j.nk2017120108
基于社区人群的慢性乙型肝炎病毒感染孕妇产前血清学及病毒学特征
Prenatal serological and virological characteristics of pregnant women with chronic HBV infection in community population
摘要
Abstract
Objective To investigate the prenatal serological and virological characteristics of HBsAg-positive pregnant women without in some areas in China.Methods A total of 1741 HBsAg-positive pregnant women were recruited from Guangxi,Jiangsu and Henan provinces.Serum samples were collected before labor for evaluation of pre-delivery ALT,HBV serological markers and HBV DNA.HBsAg,HBeAg and HBV DNA levels were tested by Abbott Architect i2000 and m2000 systems,respectively.HBV genotyping was performed by a method based on nested polymerase chain reaction (nPCR) established in our lab.Results Among 1741 HBsAgpositive women,37.0％(645/1741) were HBeAg positive and 63.0％(1096/1741) were HBeAg negative,respectively.The median titers of HBsAg,HBV DNA levels and the proportion of genotype B in HBeAg-positive women were higher than those of HBeAg-negative women,but the age of HBeAg-positive women was younger than that of HBeAg-negative ones.The proportion of HBeAg-positive women was gradually declining with the increase of age.HBsAg titers and HBeAg titers were positively correlated with HBV DNA levels in HBeAg-positive group (r=0.790,P＜0.001;r=0.564,P＜0.001).However,there was no correlation between HBsAg titers and HBV DNA levels in HBeAg-negative group (r=0.020,P=0.517).Conclusion The serological and virological characteristics of treatmentnaive HBsAg-positive women differed by the HBeAg status.Quantitative HBsAg titer and HBeAg titer might be surrogate markers for HBV DNA levels in HBeAg-positive women.关键词
乙型肝炎病毒/孕妇/乙型肝炎病毒表面抗原/乙型肝炎病毒e抗原/HBV DNAKey words
hepatits B virus/pregnant women/HBsAg/HBeAg/HBV DNA分类
医药卫生引用本文复制引用
卫凯平,张欣,刘秩秀,肖义炜,李杰,卢颖,闫玲,刘建勋,翟祥军,常战军,朱凤才,李荣成,李艳萍..基于社区人群的慢性乙型肝炎病毒感染孕妇产前血清学及病毒学特征[J].中国实用内科杂志,2017,37(12):1074-1078,5.基金项目
国家“十二五”艾滋病和病毒性肝炎等重大传染病防治科技重大专项(2012ZX10002001-001) （2012ZX10002001-001）
