中国药业2018，Vol.27Issue(1)：20-23,4.DOI:10.3969/j.issn.1006-4931.2018.01.006
四季草颗粒纯化工艺改进研究
Improvement of Purification Process of Sijicao Granules
摘要
Abstract
Objective To investigate a new purification process to substitute the original process for Sijicao Granules. Methods With quercetin and total solids as the evaluation indexes, the best clarifier was selected from five kinds of commonly used clarifier. The optimal clarifier was optimized by orthogonal test. Finally, the best clarification process was compared with the traditional alcohol precipitation process, and the comprehensive evaluation of the adsorption clarification process was carried out. Results The optimized adsorption clarifier was chitosan, and the conditions were as follows: the extract was concentrated to 1 : 8[crude drug(g) : liquid(mL) ], the pH of extraction solution was 4, and 100 mL 1％ chitosan glacial acetic acid solution was added into every 1 L drug solution. Conclusion The chitosan adsorption clarification process has the characteristics of simple process, low cost, and less loss of active ingredient, which can be used in the preparation of Sijicao Granules instead of the traditional process.关键词
四季草颗粒/纯化工艺/工艺改进Key words
Sijicao Granules/purification process/process improvement分类
化学化工引用本文复制引用
庞秀清,李勇军,何迅..四季草颗粒纯化工艺改进研究[J].中国药业,2018,27(1):20-23,4.基金项目
2016年贵州省科技创新人才团队建设计划项目[黔科合平台人才〔2016〕5613号]. （）
