中国药业2018，Vol.27Issue(1)：64-66,3.DOI:10.3969/j.issn.1006-4931.2018.01.021
不同抗凝方式对急性肾损伤患者持续性肾脏替代治疗的疗效比较
Comparative Effect of Different Anticoagulation Methods on Continuous Renal Replacement Therapy in Patients with Acute Kidney Injury
吴青 1陈新 1周小华 1张国培 1邹其银 1季宏建1
作者信息
- 1. 江苏省盐城市第三人民医院,江苏 盐城 224001
- 折叠
摘要
Abstract
Objective To compare the effects of anticoagulation methods with topical use of citrate or systemic use of heparin on continuous renal replacement therapy(CRRT) in patients with acute kidney injury(AKI) . Methods Totally 62 patients with AKI were divided into the citrate group(28 cases) and the heparin group(34 cases) according to different anticoagulant schemes. The life length of the hemofilter, the occurrence of adverse events during the treatment and the 30 d survival conditionsd in the two groups were analyzed. Results The life length of the hemofilter in the citrate group was (49 ± 29) h, which was significantly longer than (28 ± 23) h in the heparin group( P < 0. 05) . The incidence rate of adverse events of hemorrhage in the citrate group was 3. 57％ , which was significantly lower than 23. 53％ in the heparin group( P < 0. 05). The 30 d survival rates of the two groups were 61. 76％ and 57. 14％ , respectively, and the difference was not statistically significant ( P > 0. 05 ) . Conclusion Topical use of citrate can be widely used in anticoagulation therapy for CRRT in patients with AKI, it has obvious advantages in prolonging the use of hemofilter and reducing adverse events, but it has no obvious advantage on the short - term survival rate of the patients.关键词
急性肾损伤/持续性肾脏替代治疗/抗凝/疗效/生存率Key words
acute kidney injury/continuous renal replacement therapy/anticoagulation/curative effect/survival rate分类
医药卫生引用本文复制引用
吴青,陈新,周小华,张国培,邹其银,季宏建..不同抗凝方式对急性肾损伤患者持续性肾脏替代治疗的疗效比较[J].中国药业,2018,27(1):64-66,3.
