中国药业2018，Vol.27Issue(2)：11-15,5.DOI:10.3969/j.issn.1006-4931.2018.02.003
自由基引发剂对环糊精整体柱手性分离能力的影响研究
Effect of Radical Initiator on Enantioseparation Ability of Cyclodextrin Functionalized Polymethacrylate Monoliths
摘要
Abstract
Objective To investigate the effect of radical initiator on the enantioseparation ability of β-cyclodextrin(β-CD) functionalized monolithic capillary column.Methods Two poly(GMA-EDA-β-CD-co-MBA) monolithic columns have been prepared by using hydrosoluble initiator 2,2′-azobis(2-methylpropionamidine) dihydrochloride(AIBA) and hydrophobic initiator 2,2′-azobis(2-methyl-propionitrile) (AIBN),respectively.Their differences of chemical properties(DSC analysis and elemental analysis),physical properties (permeability,reproducibility and SEM) and chromatographic properties(retention mechanism and enantioseparation evaluation) were also systematically compared.Results The results demonstrated that the more hydrophilic initiator AIBA could speed up the free radical reaction,but no advantage on the enantioseparation ability of its β-CD-functionalized monolithic column was observed.Conclusion Initiator has an obvious effect on enantioseparation ability,and hydrophobic initiator AIBN has obvious advantages in the preparation of cyclodextrin polymer monolithic column.关键词
环糊精/整体柱/手性拆分/自由基引发剂Key words
β-cyclodextrin/monolithic column/enantioseparation/radical initiator分类
医药卫生引用本文复制引用
郭嘉亮,汪锦才,邓秋莹,欧阳永中,严文,李艳萍,黄文柱..自由基引发剂对环糊精整体柱手性分离能力的影响研究[J].中国药业,2018,27(2):11-15,5.基金项目
国家自然科学基金项目[81503031,21405013] （）
广东省自然科学基金项目[2014A030310506] （）
广东省科技计划项目[2016A020226004] （）
广东省中医药建设专项资金项目[34016006] （）
广东省中医药局科研项目[20161068] （）
佛山科学技术学院博士科研启动项目[gg040952] （）
国家级大学生创新训练计划项目[201711847015]. （）
