中国药业2018，Vol.27Issue(2)：38-42,5.DOI:10.3969/j.issn.1006-4931.2018.02.010
穿琥宁注射液治疗病毒性肺炎有效性与安全性Meta分析
Efficacy and Safety of Potassium Dehydroandrogrpholide Succinate Injection for Treating Viral Pneumonia:a Meta-Analysis
摘要
Abstract
Objective To systematically review the efficacy and safety of Potassium Dehydroandrogrpholide Succinate Injection for treating viral pneumonia.Methods We searched PubMed,EMbase,The Cochrane Library(Issue 8,2017),CBM,CNKI,VIP and Wan Fang Data and the China Clinical Trials Registry(www.chictr.org.cn) to collect randomized controlled trials(RCTs) of Potassium Dehydroandrogrpholide Succinate Injection for the patients with viral pneumonia from inception to August 2017.Two reviewers indepen-dently screened literature,extracted data and assessed the quality,then,Meta -analysis was performed by RevMan 5.3 software.Results A total of 10 studies involving 1653 patients were included.The results of Meta-analysis showed that:the effective rates of using Potassium Dehydroandrograpolide Succinate Injection in pediatric patients [ RR=1.19,95％ CI (1.07,1.33),P=0.001 ] and adult patients [ RR=1.45,95％ CI (1.28,1.63),P < 0.00001 ] in the Potassium Dehydroandrograpolide Succinate Injection group were higher than those in the control group.The fever clearance time [ MD= -1.11,95％ CI (-2.18,-0.04),P=0.04 ],cough relieving time [ MD = -1.68,95％ CI (-2.48,-0.89 ),P < 0.0001 ],rales disappeared time [ MD = -1.75,95％ CI (-2.24,-1.25 ),P < 0.00001 ] and the average hospitalization time [ MD= -2.68,95％ CI (-4.08,-1.28),P=0.0002 ] in the Potassium Dehy-droandrograpolide Succinate Injection group were significantly shorter than those in the control group(P < 0.05).Conclusion The cur-rent evidences show that Potassium Dehydroandrograpolide Succinate Injection in the treatment of viral pneumonia has certain advantages compared with conventional medicine,it can significantly shorten the hospitalization time and the symptoms disappearance time.关键词
穿琥宁注射液/病毒性肺炎/随机对照试验/Meta分析/系统评价Key words
Potassium Dehydroandrograpolide Succinate Injection/viral pneumonia/RCT/Meta-analysis/systematic review分类
医药卫生引用本文复制引用
陈昭燕,占美,田方圆,徐珽..穿琥宁注射液治疗病毒性肺炎有效性与安全性Meta分析[J].中国药业,2018,27(2):38-42,5.基金项目
中国药学会医院处方分析合作项目[312120242]. （）
