中国肿瘤生物治疗杂志2017，Vol.24Issue(12)：1343-1349,7.DOI:10.3872/j.issn.1007-385x.2017.12.001
T细胞免疫球蛋白黏蛋白分子-3精细化调控免疫应答的机制
Precise mechanisms by which TIM-3 regulates immune response
摘要
Abstract
Dynamic change and spatial characteristics of immune response is one of the fundamental theories of precision medical treatment.One certain immune regulator may have totally different functions under different temporal and spatial distribution.T cell immunoglobulin domain and mucin domain protein-3 (TIM-3) is a recently identified immune checkpoint inhibitor.Like PD-1 and CTLA-4,TIM-3 contributes to immune homeostasis.Recently,TIM-3 has attracted much attention as its dysregulated over-expression was approved to be associated with tumors and chronic viral infections.Strategies targeting immune checkpoints are now showing therapeutic prospect.However,the low efficiency rate,therapy resistance and even side effects still exist,which call for precise mechanisms investigation.Most of the research indicates the immune inhibitory effect of TIM-3;still,there are some reports on opposite conclusion.TIM-3 has multiple ligands,and the intra-cellular signaling mechanism is still unclear.In addition,the function and clinical significance of soluble TIM-3 protein in plasma remain unclear.If TIM-3 acquired multiple functions following the evolution of immune system,clarify the mechanisms by which TIM-3 regulates immune response will provided much important information for its further investigation.关键词
T细胞免疫球蛋白黏蛋白分子-3/免疫耐受/精细化调控/肿瘤Key words
T cell immunoglobulin and mucin-containing protein-3 (TIM-3)/immune tolerance/precise regulation/tumor分类
医药卫生引用本文复制引用
韩根成..T细胞免疫球蛋白黏蛋白分子-3精细化调控免疫应答的机制[J].中国肿瘤生物治疗杂志,2017,24(12):1343-1349,7.基金项目
国家重点基础研究发展计划(973计划)资助项目(No.2013CB530506) （973计划）
国家自然科学基金资助项目(No.81471540) （No.81471540）
北京市自然科学基金重点项目资助(No.7141007).Project supported by the National Key Basic Research Program (973 Program) of China (No.2013CB530506),the National Natural Science Foundation of China (No.81471540),and the National Natural Science Foundation of Beijing City(No.7141007) （No.7141007）
