动物医学进展2018，Vol.39Issue(1)：73-78,6.
防霉剂脱氢醋酸钠致大鼠出血试验
Hemorrage Trials Induced by Sodium Dehydroacetate in Rats
摘要
Abstract
Sodium dehydroacetate is widely used in foods,feed and cosmetics etc.as an antifungal additive, but little information is focused on its anticoagulation.Wistar rats were given with a gavage of sodium de-hydroacetate once a day for 12 d at doses of 50,100,150 and 200 mg/kg,and saline as a control.The body weight,feed consumption,prothrombin time(PT)and activated partial thromboplastin time(APTT)were measured at different time post administration.Histopathological analysis was mead for main tissues.The results showed that the body weight and feed consumption in 150 and 200 mg/kg at 3 d post administration were significantly lower than that in control,whereas those in 50 and 100 mg/kg at 7 d-10 d post adminis-tration were significantly lower than that in control(P<0.05).The weight gain of female rats was lower than that of male in whole test time period.The values of PT,APTT in groups treated by sodium de-hydroacetiate were extremely higher than that in control at experimental period(P<0.01).There were clearly differences between female and male in APTT data,which the value of APTT in female increased with increasing of dose and exposure time of sodium dehydroacetate.Some extent hemorrages in heart,liv-er,spleen,lung and kidney tissues were observed in histopathological analysis.The results showed that co-agulation diaorders or varying degrees of hemorrages in main organs may be induced by high dose sodium dehydroacetate,implying safety risk on human and animals when it is used as a food or feed additive.关键词
脱氢醋酸钠/防霉剂/凝血酶原时间/活化部分凝血酶原时间/大鼠Key words
sodium dehydroacetate/fungicide/PT/APTT/rat分类
农业科技引用本文复制引用
余峥嵘,吴银超,谢佳玉,谢阳,李楠,鲁倩倩,张雨梅..防霉剂脱氢醋酸钠致大鼠出血试验[J].动物医学进展,2018,39(1):73-78,6.基金项目
江苏高校优势学科建设工程项目 （）
江苏省产学研合作前瞻性联合研究项目(BY2015062-02) （BY2015062-02）
