南方医科大学学报2018，Vol.38Issue(1)：69-74,6.
刺激声音的听觉响应模式对清醒小鼠下丘神经元刺激特异性适应的影响
Effects of auditory response patterns on stimulus-specific adaptation of inferior colliculus neurons in awake mice
摘要
Abstract
Objective To explore whether the pattern of neuron's auditory response to a sound stimulus affects the characteristics of stimulus-specific adaptation (SSA) in awake mice. Methods The auditory responses of the neurons in the inferior colliculus to sound stimuli were recorded using microelectrodes in awake mice. The sequence of sound stimuli consisted of random combinations of pure tones of two different frequencies (f1 and f2) with different repetition rates. The auditory responses of the neurons to standard and deviant stimuli were calculated, namely s(f2)/s(f2) and d(f1)/d(f2), respectively. Three indexes of the responses were also calculated, including the firing difference index (FDI), frequency-specific index (SI), and common SSA index(CSI). Results The CSI of neurons with a greater FDI was significantly higher than that of neurons with a smaller FDI (P<0.05). The primary-like neurons showed different characteristics of SSAs in different time periods; SSA was significantly increased in the phase of sustained response compared with that at the onset of response (P<0.05). Conclusion The auditory response pattern to sound stimuli is also an important factor that affect SSA of inferior colliculus neurons in awake mice.关键词
刺激特异性适应/响应模式/清醒小鼠/下丘神经元Key words
stimulus-specific adaptation/response patterns/awake mice/inferior colliculus neurons引用本文复制引用
宋长宝,魏金星,李绿,肖中举..刺激声音的听觉响应模式对清醒小鼠下丘神经元刺激特异性适应的影响[J].南方医科大学学报,2018,38(1):69-74,6.基金项目
国家科技部973项目(2014CB943002) Supported by National Science and Technology Department 973 Project (2014CB943002). （2014CB943002）
