南方医科大学学报2018，Vol.38Issue(2)：168-173,6.DOI:10.3969/j.issn.1673-4254.2018.02.08
芍药苷对PM2.5诱导BEAS-2B细胞损害的保护作用
Protective effect of paeoniflorin against PM2.5-induced damage in BEAS-2B cells
摘要
Abstract
Objective To investigate the protective effects of paeoniflorin against PM2.5-induced damage in BEAS-2B cells and explore the possible mechanism. Methods With a factorial design, this study was performed to observe the protective effects of different doses of paeoniflorin against PM2.5-induced BEAS-2B cell growth inhibition and the effects of paeoniflorin on the contents of malondialdehyde (MDA) and intracellular reactive oxygen species (ROS) in the cell cultures. Results Exposure to increased PM2.5 concentrations caused significant decrease in the cell survival rate (P<0.05) with a clear dose-response relationship (r=-0.759, P<0.05). Treatment of the cells with paeoniflorin significantly attenuated PM2.5-induced inhibition of BEAS-2B cell survival (P<0.05), but the effect of paeoniflorin was not dose-dependent (P>0.05). PM2.5 exposure also significantly increased the contents of MDA and intracellular ROS (P<0.05), and paeoniflorin obviously antagonized these effects of PM2.5. Conclusion Paeoniflorin can protect BEAS-2B cells from PM2.5-induced growth inhibition, and the mechanism might be related to the anti-oxidant effects of paeoniflorin.关键词
芍药苷/PM2.5/BEAS-2B细胞/抗氧化Key words
paeoniflorin/PM2.5/BEAS-2B cells/anti-oxidant effects引用本文复制引用
吴晓芳,王丽云,易建华,雷剑,奥宇宏,李建军,韩晶..芍药苷对PM2.5诱导BEAS-2B细胞损害的保护作用[J].南方医科大学学报,2018,38(2):168-173,6.基金项目
中国科学院地球环境研究所黄土与第四纪地质国家重点实验室开放基金(SKLLQG1706) （SKLLQG1706）
国家自然科学基金(91543116) Supported by Open Fund of State Key Laboratory of Loess and Quaternary Geology, Institute of Earth Environment, CAS (SKLLQG1706)and National Natural Science Foundation of China (91543116). （91543116）
