南方医科大学学报2018，Vol.38Issue(2)：192-197,6.DOI:10.3969/j.issn.1673-4254.2018.02.12
术前血清白蛋白水平对非肌层浸润性膀胱癌患者行经尿道膀胱肿瘤电切术的预后价值
Prognostic value of preoperative serum albumin in patients with non-muscle-invasive bladder cancer undergoing transurethral resection of bladder tumor
摘要
Abstract
Objective To assess the value of preoperative serum albumin level in predicting the survival of patients with non-muscle-invasive bladder cancer (NMIBC) undergoing transurethral resection of bladder tumor (TURBT). Methods Two hundred and sixteen newly diagnosed patients with NMIBC who underwent TURBT between January, 2007 and April, 2012 were retrospectively analyzed. The patients were categorized into low albumin (<40 g/L) and normal albumin (≥40 g/L) groups. The patient survival was estimated using the Kaplan-Meier method, and univariate and multivariate Cox proportional analyses were used to determine the hazard ratios (HRs) for the overall survival (OS). Results Of the patients with available data, 82 (39％) and 127 (61％) patients were classified into low albumin (<40 g/L) and normal albumin (≥40 g/L) groups, respectively. Kaplan-Meier analysis showed a significantly worse 5-year OS in low albumin group than in normal albumin group (P=0.017). In the multivariate Cox regression analysis, after adjusting for confounding variables, the preoperative albumin level remained as an independent predictor for 5-year OS (HR:3.102, 95％CI:1.200-8.020, P=0.020). Conclusion A low preoperative albumin level predicts a poor 5-year OS in patients with NMIBC who underwent TURBT. Preoperative serum albumin can be a good prognostic factor for predicting survival of the patients with NMIBC treated with TURBT.关键词
膀胱尿路上皮癌/非肌层浸润性膀胱癌/经尿道膀胱肿瘤电切术/白蛋白/预后Key words
bladder urothelial carcinoma/non-muscle-invasive bladder cancer/transurethral resection of bladder tumor/albu-min/prognosis引用本文复制引用
张玥,李飞,杨帆,曾文利,林昊,翟启良,苏明强,陈自豪,谭万龙..术前血清白蛋白水平对非肌层浸润性膀胱癌患者行经尿道膀胱肿瘤电切术的预后价值[J].南方医科大学学报,2018,38(2):192-197,6.基金项目
国家自然科学基金(81272844) （81272844）
广东省科技计划项目,2013B (022000067) （022000067）
广东省自然科学基金,2015A(030313289) Supported by National Natural Science Foundation of China (81272844). （030313289）
