南方医科大学学报2018，Vol.38Issue(2)：234-238,5.DOI:10.3969/j.issn.1673-4254.2018.02.19
两种不同剂量雷洛昔芬促排卵对小鼠围着床期子宫内膜胞饮突表达的影响
Effects of raloxifene at two different doses for ovulation induction on endometrial pinopodes in mice during the implantation window
摘要
Abstract
Objective To compare the expression of pinopodes, the marker of endometrial receptivity, during the implantation window in Kunming mice stimulated with two different doses of raloxifene (RAL). Methods Forty-eight 8-week-old female Kunming mice were randomly divided into 4 groups (n=12), namely saline group, clomiphene citrate (CC, 18 mg/kg) group, RAL (33 mg/kg) group and RAL (44 mg/kg group). In each group, the mice received intragastric administration of 1 mL of normal saline containing CC or RAL at the specified doses or saline only as indicated for ovulation induction, once daily for 2 days. The mice received then injection with 5 IU human chorionic gonadotropin (HCG) and mated and on day 4.5 of gestation, the pregnant mice were sacrificed for examination of the uterus with scanning electron microscopy. Results Abundant and well developed pinopodes were observed in the endometrium of the mice in the 2 RAL groups and in the saline control group. The mice in CC group showed obviously reduced endometrial pinopodes with poor development. Conclusions RAL at two different doses does not obviously affect the expression of pinopodes in the uterine epithelium of mice, suggesting the safety of RAL at these two doses for ovulation induction without causing adverse effects on endometrial receptivity.关键词
雷洛昔芬/克罗米芬/小鼠/子宫内膜容受性/胞饮突Key words
raloxifene/clomiphene citrate/endometrial receptivity/pinopode引用本文复制引用
陈彩蓉,颜秋霞,周秀琴,冼英杰,郭晓燕,全松..两种不同剂量雷洛昔芬促排卵对小鼠围着床期子宫内膜胞饮突表达的影响[J].南方医科大学学报,2018,38(2):234-238,5.基金项目
2014年度清远市产业技术与研究开发专项资金项目(2014A002) （2014A002）
2014年度清远市社会发展领域自筹经费科技计划项目(2014B008) （2014B008）
