国际口腔医学杂志2017，Vol.44Issue(6)：619-627,9.DOI:10.7518/gjkq.2017.06.001
口腔微生物组在口腔精准医疗中的运用
Oral microbiome in the precision medicine
摘要
Abstract
Modern medicine has shifted from "disease oriented" to "patient oriented" and has consequently created a new era of personalized medicine or precision medicine.The physiological functions of the human body are determined not only by the human genome but also by symbiotic microflora.Currently,studies on the human microbiome have extended from a simple analysis of the association of bacteria and diseases to a complex analysis of the role of microbiome in the pathogenesis,diagnosis,and treatment of diseases.These breakthroughs possibly promote the practice of personalized/ precision medicine.This review summarizes the advances in oral microbiome-related research.In particular,the potential role of oral microbiome in the risk prediction,diagnosis,treatment evaluation,and prognosis of diseases is extensively discussed.Current challenges in the development of oral microbiome-based precision medicine are also described.关键词
口腔微生物组/精准医疗/组学研究/精准预警/精准诊断/精准治疗/精准疗效评估Key words
oral microbiome/precision medicine/omics/precise risk prediction/precise diagnosis/precise therapy/precise evaluation分类
医药卫生引用本文复制引用
徐欣,何金枝,周学东..口腔微生物组在口腔精准医疗中的运用[J].国际口腔医学杂志,2017,44(6):619-627,9.基金项目
国家自然科学基金(81670978,81600874) （81670978,81600874）
四川省科技厅重大前沿项目(2016JY0006) （2016JY0006）
四川大学华西口腔医院临床新技术项目(LCXJS2015-3)This study was supported by National Natural Science Foundation of China(81670978,81600874),Key Project for Frontier Research of Science and Technology Department of Sichuan Province(2016JY0006),and Clinical Innovation Grant of West China Hospital of Stomatology,Sichuan University(LCXJS2015-3). （LCXJS2015-3）
