国际口腔医学杂志2017，Vol.44Issue(6)：647-653,7.DOI:10.7518/gjkq.2017.06.005
环二腺嘌呤核苷酸信号系统及其在口腔细菌致病机制中的研究展望
Research progress on cyclic di-adenosine monophosphate signaling system and its potential role in oral bacterial pathogenesis
摘要
Abstract
Cyclic di-adenosine monophosphate(c-di-AMP) is a new signal nucleotide,widely distributed among bacteria and archaea,c-di-AMP plays an important role in the regulation of cell growth,cell wall homeostasis,interaction with host immune system and stress response.Bioinformatic analysis revealed that many oral bacterial genomes could encode the c-di-AMP synthase gene.Here we provide an overview of the synthesis and regulation of c-di-AMP in bacteria,highlighting the currently identified receptor proteins and pathways that are directly or indirectly controlled by c-di-AMP,as well as the recognition of c-di-AMP by the eukaryotic host.This review can serve as an important reference for future research of the c-di-AMP signaling system in oral bacteria.关键词
环二腺嘌呤核苷酸/口腔细菌/信号传递/致病机制Key words
cyclic di-adenosine monophosphate/oral bacteria/signaling transduction/pathogenesis分类
医药卫生引用本文复制引用
程兴群,徐欣,周学东,李雨庆..环二腺嘌呤核苷酸信号系统及其在口腔细菌致病机制中的研究展望[J].国际口腔医学杂志,2017,44(6):647-653,7.基金项目
国家自然科学基金(31200985,81430011)This study was supported by National Natural Science Fundation of China(31200985,81430011). （31200985,81430011）
