国际口腔医学杂志2017，Vol.44Issue(6)：660-663,4.DOI:10.7518/gjkq.2017.06.007
细胞焦亡与牙龈卟啉单胞菌的关系及其在牙周病发生发展中的作用机制
Mechanism of pyroptosis and Porphyromonas gingivalis in periodontitis development process
摘要
Abstract
Pyroptosis is a typical form of programmed cell death mediated by inflammasomes.It leads to inflammatory response through the release of pro-inflammatory cytokines.Porphyromonas gingivalis is the keystone pathogen of periodontitis.On the one hand,it can activate the nucleotide-binding oligomerization domain like receptor protein 3 inflammasomes of macrophages in the periodontal tissue,and it also can promote pyroptosis that lead to the immune pathological damage of periodontal tissue;on the other hand,it restrain the pyroptosis of vascular endothelial cell and escape the killing of the immune system.In this paper,the recent progress and mechanism of pyroptosis in periodontitis are reviewed.关键词
牙周炎/细胞焦亡/作用机制Key words
periodontitis/pyroptosis/mechanism分类
医药卫生引用本文复制引用
唐秋玲,李格格,潘佳慧,侯玉帛,孟阳,于维先..细胞焦亡与牙龈卟啉单胞菌的关系及其在牙周病发生发展中的作用机制[J].国际口腔医学杂志,2017,44(6):660-663,4.基金项目
国家自然科学基金面上项目(81570983) （81570983）
吉林省科技厅自然科学基金项目(2015010l076JC)This study was supported by National Natural Science Foundation of China(81570983) and Natural Science Foundation of Science and Technology Department of Jilin Province(20150101076JC). （2015010l076JC）
