国际口腔医学杂志2017，Vol.44Issue(6)：674-678,5.DOI:10.7518/gjkq.2017.06.010
齿垢密螺旋体糜蛋白酶样蛋白酶复合物及其致病作用
Treponema denticola chymotrypsin-like protease complex and its pathogenic features
摘要
Abstract
Treponema denticola is closely associated with periodontal disease as a member of subgingival "red complex".The surface protease chymotrypsin-like protease complex(CTLP) is an important virulent factor of T.denticola.CTLP plays significant roles in mediating pathogenesis of T.denticola,including adhesion and invasion to host cells and proteins,synergetic formation of biofilm with other periodontal pathogens,cytopathic effect,impairment and penetration of epithelial barrier,degradation of cell and tissue protein,modulation of host-derived proteinases and disruption of host immune regulation,and displaying multiple pathogenic features.Further study of CTLP will help to explain the pathogenesis of oral leptospira and to enrich the etiology and pathogenesis of periodontal diseases.关键词
牙周病/齿垢密螺旋体/糜蛋白酶样蛋白酶复合物Key words
periodontal disease/Treponema denticola/chymotrypsin-like protease complex分类
生物科学引用本文复制引用
苗棣,吴亚菲..齿垢密螺旋体糜蛋白酶样蛋白酶复合物及其致病作用[J].国际口腔医学杂志,2017,44(6):674-678,5.基金项目
西安交通大学基本科研业务费自由探索类项目(xjj2013068)This study was supported by Fundamental Research Funds of Xi'an Jiaotong University for Free Exploration Project(xjj2013068). （xjj2013068）
