国际病理科学与临床杂志2017，Vol.37Issue(10)：2050-2056,7.DOI:10.3978/j.issn.2095-6959.2017.10.005
P53和ATRX蛋白在IDH1突变型与野生型胶质母细胞瘤表达的相关性及生物学意义
Correlation and biological significance of P53 and ATRX protein expression in IDH1 mutant and wild type glioblastoma
摘要
Abstract
Objective:To investigate the correlation between P53 and ATRX protein expression in IDH1 mutant and wild type glioblastoma (GBM) and its biological significance.Methods:A total of 62 cases of tissue samples were collected from the Department of Pathology of Guangdong Tongjiang Hospital (including 12 cases of IDH1 mutant GBM,50 cases of IDH1 wild type GBM detected by immunohistochemistry).The expression of P53 and ATRX protein in these two different genotyping GBMs were detected and their relationship with prognosis were analyzed.Results:The expression rates of P53 protein in IDH1 mutant and wild type GBM were 75.00％ (9/12) and 30.00％ (15/50) respectively,and the expression rates of ATRX protein were 16.67％ (2/12) and 94.00％ (47/50),respectively.The expression of P53 and ATRX protein in the two genotypes of IDH1 was statistically significant (P＜0.01).P53 and ATRX were negatively correlated (r=-0.404,P＜0.01).Cox multiple regression analysis showed that IDH1 genotype,age and sex were the risk factors of GBM survival (P＜0.01).Conclusion:Most of the IDH1 wild-type GBM patients lack the P53 gene and the ATRX gene mutation.IDH1 wild-type GBM is a significant factor affecting the survival time of GBM,which can be used as one of the important indexes to judge the prognosis of adult GBM patients.关键词
IDH1突变型胶质母细胞瘤/IDH1野生型胶质母细胞瘤/P53/ATRX/预后Key words
IDH1 mutant glioblastoma/IDH1 wild type glioblastoma/P53/ATRX/prognosis引用本文复制引用
潘斌才,梁颖雯,王春华,黄桂芳,徐伟玲,黄嘉裕,伏慧..P53和ATRX蛋白在IDH1突变型与野生型胶质母细胞瘤表达的相关性及生物学意义[J].国际病理科学与临床杂志,2017,37(10):2050-2056,7.基金项目
佛山市医学类科技攻关项目(2016AB003733).This work was supported by Medical Science and Technology Project of Foshan,China (2016AB003733). （2016AB003733）
