临床与病理杂志2017，Vol.37Issue(10)：2062-2066,5.DOI:10.3978/j.issn.2095-6959.2017.10.007
SUMO特异性蛋白酶1和ERα在Ⅰ型子宫内膜癌组织中的表达及其临床意义
Expression and significance of SUMO specific protease 1 and ERα in type-Ⅰ endometrial carcinoma
摘要
Abstract
Objective:To investigate the expression and relationship of SUMO specific protease 1 (SENP1) and ERa in type-1 endometrial carcinoma.Methods:Fifty endometrial cancer cases were involved in this study.Immunohistochemical method was performed to study SENP1 protein and estrogen receptor (ER) expression in endometrial cancer tissues and para-carcinoma tissues.Correlations between SENP1 and ERα,as well as clinical pathological parameters were also analyzed.Results:Expression of SENP1 protein in type-1 endometrial carcinoma was significantly higher than that in the para-cancer tissues.Expression of SENP1 protein was significantly higher in well-differentiated tumors than in poorly-differentiated tumors.Expression of SENP1 was positively correlated with the expression of ERα,but not with the age of patients,the depth of tumor invasion,tumor stage and lymph node metastasis.Conclusion:SENP1 may play an important role in the occurrence and development of type-1 endometrial carcinoma,which may be a new target for the treatment of endometrial carcinoma.关键词
子宫内膜癌/SUMO特异性蛋白酶1/雌激素受体/免疫组织化学Key words
endometrial carcinoma/SUMO specific protease 1/estrogen receptor/immunohistochemistry引用本文复制引用
崔鑫,张采欣,李云辉,亓永云,丁晓燕,黑淑敏,黄维清..SUMO特异性蛋白酶1和ERα在Ⅰ型子宫内膜癌组织中的表达及其临床意义[J].临床与病理杂志,2017,37(10):2062-2066,5.基金项目
青岛市医疗卫生重点学科建设项目.This work was supported by Qingdao Key Health Discipline Development Fund,China. （）
