临床与病理杂志2017，Vol.37Issue(10)：2067-2071,5.DOI:10.3978/j.issn.2095-6959.2017.10.008
乳腺癌中EZH2,MMP-2和MMP-9蛋白表达及其临床意义
Expression of EZH2, MMP-2 and MMP-9 in breast cancer and their clinical significance
摘要
Abstract
Objective:To explore the expression of enhancer of zeste homolog 2 (EZH2),MMP-2 and MMP-9 in breast cancer and to analyze their relationship with the clinical pathologic characteristics.Methods:The expression of EZH2,MMP-2 and MMP-9 protein were detected by SP immunohistochemical method in 147 breast cancer tissues,58 normal breast tissues and 58 benign breast tumor tissues,and the relationship among the three groups were analysed.The correlation of the EZH2,MMP-2 and MMP-9 protein expression with the clinicopathological features were also analyzed.Results:Positive intensity of EZH2,MMP-2 and MMP-9 in breast cancer were significantly higher than that in normal breast tissues and benign breast tumor (P＜0.001).In breast cancer the expression of EZH2,MMP-2 and MMP-9 were not correlated with patient age,menopausal status,the tumor size and histological types,but were correlated with the lymph node metastasis (P＜0.001).Conclusion:EZH2,MMP-2 and MMP-9 may be closely related to the pathogenesis and progression of breast cancer.The joint detection of the 3 indictors of EZH2,MMP-2 and MMP-9 in human breast cancer tissue may contribute to cancer diagnosis and treatment,and provide a reference to the study of breast cancer.关键词
乳腺癌/组蛋白甲基转移酶/MMP-2/MMP-9Key words
breast cancer/enhancer of zeste homolog 2/MMP-2/MMP-9引用本文复制引用
嵇晓辉,闫琛,刘红伟,杨金花..乳腺癌中EZH2,MMP-2和MMP-9蛋白表达及其临床意义[J].临床与病理杂志,2017,37(10):2067-2071,5.
