临床与病理杂志2017，Vol.37Issue(10)：2220-2223,4.DOI:10.3978/j.issn.2095-6959.2017.10.032
Cyr61/CCN1在创面愈合中的研究进展
Research progress in Cyr61/CCN1 in wound healing
摘要
Abstract
Cyr61/CCN1 (cysteine-rich 61) is one of the focuses of biomedical research at home and abroad in recent years.Cyr61 forms p130Cas/CrkⅡ signal complexes via avβ3/avβ5,allowing FAK to phosphorylate and further activates the Rac1 signal pathway to promote the role ofneutrophils in the burial effect to reduce the inflammatory response of wound to accelerate healing.During the tissue repair phase,the combination ofintegrin a6β1 induces fibroblast senescence or activates p16 INK4a/pRb signaling to further inhibit the expression of fibrosis factor,thereby inhibiting the occurrence of fibrosis.It plays an important role both in inflammation and repair phase.The potential therapeutic value is to accelerate the stage of inflammation and inhibit the fibrosis of the repair stage and reduce the scar tissue.More in-depth understanding of the role of Cyr61 and skin wound healing relationship is useful to the development of safe and effective clinical treatment programs and drugs.关键词
Cyr61/CCN1/创面愈合/炎症/组织修复Key words
Cyr61/CCN1/wound healing/inflammation/tissue repair引用本文复制引用
蒯仂,许逊哲,茹意,魏冬慧,吴人杰,王一花..Cyr61/CCN1在创面愈合中的研究进展[J].临床与病理杂志,2017,37(10):2220-2223,4.基金项目
国家自然科学基金(81473682) （81473682）
国家基础科学人才培养基金项目(J1103607) （J1103607）
上海市卫计委项目(ZY3-CCCX-3-3033) （ZY3-CCCX-3-3033）
上海市科委项目(14401970200) （14401970200）
上海中医药大学第十批大学生科技创新项目(JX61.08.97,JX61.08.98).This work was supported by the National Natural Science Foundation (81373648),National Science and Technology Major Project Foundation (J1103607),the Project of Shanghai Health Bureau (ZY3-CCCX-3-3033),the Project of Shanghai Science and Technology Commission (14401970200) and the 10th College Students Science and Technological Innovation Project of Shanghai University TCM (JX61.08.97,JX61.08.98),China. （JX61.08.97,JX61.08.98）
