临床与病理杂志2017，Vol.37Issue(10)：2237-2242,6.DOI:10.3978/j.issn.2095-6959.2017.10.035
骨髓增生异常综合征中常见的基因突变及其临床意义
Gene mutations and its clinical significance in myelodysplastic syndrome
张阳 1刘铭2
作者信息
- 1. 河北燕达陆道培医院病理和检验医学科,河北廊坊065201
- 2. 青岛大学附属医院血液科,山东青岛266003
- 折叠
摘要
Abstract
Myelodysplastic syndrome (MDS) is a group of stem cell clonal diseases that are biologically and clinically heterogeneous.Due to lack of specific markers in the diagnosis,treatment,clinical prognosis and disease monitoring of MDS,it often brings confusion for correct diagnosis and treatment.With advances in precision medicine and molecular biology,more than 50 kinds of mutant genes have been reported involved in the pathogenesis of MDS.Combination of these mutations is closely related to the occurrence and development of MDS,treatment response and prognosis,and provides an important basis for the diagnosis and treatment of MDS.关键词
骨髓增生异常综合征/基因突变/突变组/精准医疗Key words
myelodysplastic syndrome/gene mutation/mutaome/precision medicine引用本文复制引用
张阳,刘铭..骨髓增生异常综合征中常见的基因突变及其临床意义[J].临床与病理杂志,2017,37(10):2237-2242,6.
