海南医学院学报2017，Vol.23Issue(21)：2921-2924,2928,5.DOI:10.13210/j.cnki.jhmu.20171026.003
左西孟旦辅助治疗对老年慢性心力衰竭患者神经内分泌激素及细胞因子的影响
Effect of adjuvant levosimendan therapy on neuroendocrine hormones and cytokines in elderly patients with chronic heart failure
摘要
Abstract
Objective:To discuss the effect of adjuvant levosimendan therapy on neuroendocrine hormones and cytokines in elderly patients with chronic heart failure.Methods:100 elderly patients with chronic heart failure who were treated in the hospital between March 2014 and March 2017 were divided into control group and levosimendan group by random number table,each with 50 cases.Control group received clinical routine therapy for chronic heart failure,and levosimendan group received routine therapy combined with adjuvant levosimendan therapy.The differences in serum levels of RAAS indexes,thyroid hormones,myocardial damage indexes and endothelial function indexes were compared between the two groups before and after treatment.Results:At T0,there was no statistically significant difference in serum levels of RAAS indexes,thyroid hormones,myocardial damage indexes and endothelial function indexes between the two groups (P＞0.05).At T1,serum RAAS indexes PRA,Ang Ⅱ and ALD levels of levosimendan group were lower than those of control group;serum thyroid hormones TT3,TT4,FT3 and FT4 levels of levosimendan group were higher than those of control group;serum myocardial damage in dexes cTn Ⅰ,H-FABP and NT-proBNP levels of levosimendan group were lower than those of control group;serum endothelial function index NO level of levosimendan group was higher than that of control group while ET 1 level was lower than that of control group.Conclusion:Adjuvant levosimendan therapy for elderly patients with chronic heart failure can effectively adjust the secretion of neuroendocrine hormones and reduce the myocardial and vascular endothelial damage.关键词
老年慢性心力衰竭/左西孟旦/神经内分泌激素Key words
elderly chronic heart failure/levosimendan/neuroendocrine hormone分类
医药卫生引用本文复制引用
雷莉,袁宇峰..左西孟旦辅助治疗对老年慢性心力衰竭患者神经内分泌激素及细胞因子的影响[J].海南医学院学报,2017,23(21):2921-2924,2928,5.基金项目
延安市科学技术研究发展计划项目(2014HM-07)Yanan science and technology research and development project (2014HM-07) （2014HM-07）
