海南医学院学报2017，Vol.23Issue(21)：3006-3009,4.DOI:10.13210/j.cnki.jhmu.20171030.003
亚低温干预对急性颅脑损伤患者神经损伤程度及神经递质、炎症介质的影响
Effect of mild hypothermia intervention on the nerve injury as well as neurotransmitters and inflammatory mediators in patients with acute craniocerebral injury
摘要
Abstract
Objective:To explore the effect of mild hypothermia intervention on the nerve injury as well as neurotransmitters and inflammatory mediators in patients with acute craniocerebral injury.Methods:700 patients with acute craniocerebral injury who were treated in Lueyang People's Hospital between March 2014 and March 2017 were collected and divided into routine group (n =350) and mild hypothermia group (n =350) by random number table.Routine group accepted craniotomy evacuation of hematoma,and mild hypothermia group accepted mild hypothermia intervention on the basis of craniotomy evacuation of hematoma.The differences in the serum contents of nerve injury-related indexes,amino acid neurotransmitters and inflammatory mediators were compared between the two groups before and after treatment.Results:Before treatment,there was no statistically significant difference in the serum levels of nerve injury-related indexes,amino acid neurotransmitters and in flammatory mediators between the two groups.After treatment,serum nerve injury-related indexes NSE,S100B,Nogo-A and MBP levels of mild hypothermia group were lower than those of routine group;serum amino acid neurotransmitters Asp and Glu levels of mild hypothermia group were lower than those of routine group while GABA level was higher than that of routine group;serum inflammatory mediators HMGB1,IL-8 and TNF-α levels of mild hypothermia group were lower than those of routine group.Conclusion:Early mild hypothcrmia intervention can effectively relieve the nerve injury in patients with acute craniocerebral injury and exert positive neuroprotective effect.关键词
急性颅脑损伤/亚低温干预/神经损伤/神经递质/炎性介质Key words
acute craniocerebral injury/mild hypothermia intervention/nerve injury/neurotransmitter/inflammatory mediator分类
医药卫生引用本文复制引用
李金平,李世龙..亚低温干预对急性颅脑损伤患者神经损伤程度及神经递质、炎症介质的影响[J].海南医学院学报,2017,23(21):3006-3009,4.基金项目
陕西省科学技术研究发展计划项目(2011k13-02-06)Shaanxi Provincial Science and Technology Research and Development Program (2011k13-02-06) （2011k13-02-06）
