海南医学院学报2017，Vol.23Issue(21)：3025-3027,3031,4.DOI:10.13210/j.cnki.jhmu.20171030.002
增强CT定量参数与胰腺癌病灶内增殖、侵袭基因表达量的相关性
The correlation of contrast-enhanced CT quantitative parameters with proliferation and invasion gene expression in pancreatic cancer
摘要
Abstract
Objective:To discuss the correlation of contrast-enhanced CT quantitative parameters with proliferation and invasion gene expression in pancreatic cancer.Methods:100 patients with pancreatic cancer who were treated in the hospital between May 2015 and May 2017 were selected as pancreatic cancer group,and 48 patients with necrotic pancreatitis who received surgical treatment in the hospital during the same period were selected as pancreatitis group.Differences in pancreatic contrastenhanced CT value as well as the expression of proliferation-related genes and invasion-related genes in lesion tissue were compared between the two groups,and Pearson test was used to evaluate the correlation of pancreatic cancer tissue CT value with proliferation and invasion gene expression.Results:Contrast-enhanced CT value of pancreatic cancer tissue was lower than that of pancreatitis tissue;proliferation-related genes Bmi-1,Ezrin and FOXC1 mRNA expression in lesion tissue of pancreatic cancer group were higher than those of pancreatitis group while EphB2 and RGC-32 mRNA expression were lower than those of pancreatitis group;invasion-related genes FHL1,JDP2,Let-7f and TFPI-2 mRNA expression in lesion tissue of pancreatic cancer group were lower than those of pancreatitis group while Twist and HOXB7 mRNA expression were higher than those of pancreatitis group.Pearson test showed that the contrast-enhanced CT value of pancreatic cancer was directly correlated with the proliferation and invasion gene expression in lesion tissue.Conclusion:Contrast-enhanced CT value of pancreatic cancer tissue was lower than that of normal pancreas tissue,and the specific CT value was directly correlated with the tumor proliferation and invasion related gene expression,and can be used as a simple and reliable method for early diagnosis of disease and judgement of illness severity.关键词
胰腺癌/增强CT/增殖基因/侵袭基因Key words
pancreatic cancer/contrast-enhanced CT/proliferation gene/invasion gene分类
医药卫生引用本文复制引用
毛卫霞,韩文..增强CT定量参数与胰腺癌病灶内增殖、侵袭基因表达量的相关性[J].海南医学院学报,2017,23(21):3025-3027,3031,4.基金项目
陕西省教育厅资助项目(2010H25)Shaanxi Provincial Department of Education funded projects (2010H25) （2010H25）
