海南医学院学报2017，Vol.23Issue(21)：3039-3042,4.DOI:10.13210/j.cnki.jhmu.20171013.005
压力性尿失禁患者盆底特征的超声定量评价及其与细胞外基质重塑、细胞凋亡的相关性
The ultrasonic quantitative evaluation of pelvic floor characteristics in patients with stress urinary incontinence and the correlation with extracellular matrix remodeling and apoptosis
摘要
Abstract
Objective:To study the ultrasonic quantitative evaluation of pelvic floor characteristics in patients with stress urinary incontinence and the correlation with extracellular matrix remodeling and apoptosis.Methods:Patients with stress urinary incontinence who received surgical treatment in Xuzhou Central Hospital between February 2015 and April 2017 were selected as the SUI group of the research,female healthy volunteers who received physical examination during the same period were selected as the control group A of the research,and patients who received total hysterectomy for benign disease during the same period were selected as the control group B of the research.The ultrasound parameters of pelvic floor characteristics of SUI group and control group A were determined before surgery,and the contents of collagen metabolism indexes,extracellular matrix metabolism indexes and apoptosis genes of SUI group and control group B were determined after surgery.Results:Pelvic floor ultrasound parameters BND,R RVA,V-RVA and UR levels of SUI group were higher than those of control groupA;Col-Ⅰ and Col Ⅱ contents as well as Fibulin-5,LOX and LOXL1 mRNA expression in pelvic floor tissue of SUI group weresignificantly lower than those of control group B and negatively correlated with pelvic ultrasound parameter BND while ICTPcontent as well as Calpain1,Calpain2,Caspase-3,LC3-Ⅱ and Beclin-1 mRNA expression was significantly higher than those ofcontrol group B and positively correlated with pelvic floor ultrasound parameter BND.Conclusion..The patients with stress urinary incontinence have the ultrasonic characteristics of weak pelvic support and enhanced urethral activity,and the abnormalcollagen metabolism and excessive apoptosis are closely related to the changes of pelvic floor.关键词
压力性尿失禁/盆底超声/细胞外基质/细胞凋亡Key words
stress urinary incontinence/pelvic floor ultrasound/extracellular matrix/apoptosis分类
医药卫生引用本文复制引用
郁丁,温玉玲..压力性尿失禁患者盆底特征的超声定量评价及其与细胞外基质重塑、细胞凋亡的相关性[J].海南医学院学报,2017,23(21):3039-3042,4.基金项目
江苏省科技计划项目(SBE2015720130)Jiangsu science and technology project (SBE2015720130) （SBE2015720130）
