海南医学院学报2018，Vol.24Issue(1)：71-74,4.DOI:10.13210/j.cnki.jhmu.20171208.005
甲状腺癌细针穿刺组织中S100A13、FOXA1表达量与细胞周期、细胞侵袭的相关性
The correlation of S100A13 and FOXA1 expression with cell cycle and cell invasion in fine needle aspiration thyroid carcinoma tissue
摘要
Abstract
Objective:To study the correlation of S100A13 and FOXA1 expression with cell cycle and cell invasion in fine needle aspiration thyroid carcinoma tissue .Methods:Patients who received ultrasound-guided thyroid nodule fine needle as-piration in Haiyang People's Hospital between April 2015 and February 2017 were selected ,and the tissues were divided into malignant thyroid tissue and benign thyroid nodules according to the pathological results after biopsy .The expression of S100A13 ,FOXA1 ,cell cycle molecules and cell invasion molecules were measured .Results:S100A13 ,FOXA1 ,CDK2 ,Cy-clinD1 ,MCM2 ,MCM7 ,SKP2 ,CLOCK ,STAT3 ,STAT5 ,N-cadherin ,MT1-MMP and ADAM17 mRNA expression in thyroid carcinoma tissue were significantly higher than those in benign thyroid nodule ;CDK2 ,CyclinD1 ,MCM2 ,MCM7 ,SKP2 and CLOCK mRNA expression in thyroid carcinoma tissue with high FOXA 1 expression were significantly higher than those in thyroid carcinoma tissue with low FOXA1 expression;STAT3 ,STAT5 ,N-cadherin ,MT1-MMP and ADAM17 mR-NA expression in thyroid carcinoma tissue with high S100A13 expression were significantly higher than those in thyroid cancer tissue with low S100A13 expression .Conclusion:High expression of S100A13 and FOXA1 in thyroid carcinoma can promote cell invasion and cell cycle progression .关键词
甲状腺癌/细针穿刺/S100A13、FOXA1/细胞周期/细胞侵袭Key words
thyroid carcinoma/fine needle aspiration/S100A13/FOXA1/cell cycle/cell invasion分类
医药卫生引用本文复制引用
殷月玲,于晓东..甲状腺癌细针穿刺组织中S100A13、FOXA1表达量与细胞周期、细胞侵袭的相关性[J].海南医学院学报,2018,24(1):71-74,4.基金项目
Haiyang science and technology development program (2016052) 海阳市科技发展计划项目(2016052) （2016052）
