海南医学院学报2018，Vol.24Issue(1)：75-78,4.DOI:10.13210/j.cnki.jhmu.20171227.002
益气养阴方联合放疗对晚期肺癌患者肿瘤负荷及抗肿瘤免疫应答的影响
Effects of Yiqi Yangyin Prescription combined with radiotherapy on the tumor load and anti-tumor immune response in patients with advanced lung cancer
摘要
Abstract
Objective:To investigate the effects of Yiqi Yangyin Prescription combined with radiotherapy on the tumor load and anti-tumor immune response of patients with advanced lung cancer .Methods:A total of 78 patients with advanced non-small cell lung cancer who were diagnosed and treated in our hospital between August 2015 and January 2017 were reviewed and then divided into the routine group (n=41) who received chemoradiotherapy alone and the Yiqi Yangyin Prescription group (n=37) who received chemoradiotherapy combined with Yiqi Yangyin Prescription therapy .The differences in serum levels of tumor markers ,Th1/Th2 cytokines and Th17/Treg cytokines were compared between the two groups before and after treat-ment .Results:After treatment ,serum tumor markers CA15-3 ,Cyfra21-1 ,HSP90αand CEA levels of Yiqi Yangyin Prescrip-tion group were lower than those of routine group ;serum Th1 cytokines IFN-γand IL-2 levels were higher than those of rou-tine group while Th2 cytokines IL-4 and IL-5 levels were lower than those of routine group ;serum Th17 cytokines IL-17 and IL-23 as well as Treg cytokines IL-10 and TGF-βlevels were lower than those of routine group .Conclusion:Routine chemora-diotherapy combined with Yiqi Yangyin Prescription therapy can effectively reduce the tumor load and optimize the anti-tumor immune function in patients with advanced non-small cell lung cancer .关键词
晚期肺癌/益气养阴方/肿瘤负荷/Th1/Th2/Th17/TregKey words
Advanced lung cancer/Yiqi Yangyin Prescription/Tumor load/Th1/Th2/Th17/Treg分类
医药卫生引用本文复制引用
乔志安..益气养阴方联合放疗对晚期肺癌患者肿瘤负荷及抗肿瘤免疫应答的影响[J].海南医学院学报,2018,24(1):75-78,4.基金项目
This study was supported by the Science and Technology Plan Project of Hebei Province (162777186). 河北省科技计划项目(162777186) （162777186）
