海南医学院学报2018，Vol.24Issue(1)：101-104,4.DOI:10.13210/j.cnki.jhmu.20171120.032
宫颈癌病灶内SFRP2、TPX2表达量与癌细胞凋亡、EMT过程的相关性
Correlation of SFRP2 and TPX2 expression with cancer cell apoptosis and EMT process in cervi cal cancer
摘要
Abstract
Objective:To study the correlation of SFRP2 and TPX2 expression with cancer cell apoptosis and EMT process in cervical cancer .Methods:Patients with cervical cancer who received surgical resection in No 1.74 Hospital of PLA be-tween June 2015 and December 2016 were selected as the research subjects ,moderate amount of cervical cancer lesion and adja-cent lesion were collected after surgical resection to extract RNA ,and then fluorescent quantitative PCR kit was used to deter-mine the expression of SFRP2 ,TPX2 ,apoptosis genes and EMT genes in lesion tissue .Results:SFRP2 ,SARI ,AIF ,FHIT , NDRG4 ,MCPH1 and E-cadherin mRNA expression in cervical cancer lesion were greatly lower than those in adjacent lesions whereas TPX2 ,SP2 ,CyclinD1 ,Piwil2 ,HERC4 ,EFEMP1 ,EZH2 ,TGF-β1 ,N-cadherin and Vimentin1 mRNA expression were greatly higher than those in adjacent lesions ;SFRP2 mRNA expression in cervical cancer lesion was positively correlated with SARI ,AIF ,FHIT ,NDRG4 ,MCPH1 and E-cadherin mRNA expression ,and negatively correlated with SP2 ,CyclinD1 , Piwil2 ,HERC4 ,EFEMP1 ,EZH2 ,TGF-β1 ,N-cadherin and Vimentin1 mRNA expression whereas TPX2 mRNA expression was negatively correlated with SARI ,AIF ,FHIT ,NDRG4 ,MCPH1 and E-cadherin mRNA expression ,and positively corre-lated with SP2 ,CyclinD1 ,Piwil2 ,HERC4 ,EFEMP1 ,EZH2 ,TGF-β1 ,N-cadherin and Vimentin1 mRNA expression .Con-clusions:The lowly expressed SFRP2 and highly expressed TPX2 in cervical cancer lesions can inhibit the apoptosis of cancer cells and promote the EM T process of cancer cells .关键词
宫颈癌/分泌型卷曲相关蛋白2/Xklp2靶蛋白Key words
cancer/Secreted frizzled-related protein 2/Targeting protein for Xklp2分类
医药卫生引用本文复制引用
郑朝坂,李玉萍..宫颈癌病灶内SFRP2、TPX2表达量与癌细胞凋亡、EMT过程的相关性[J].海南医学院学报,2018,24(1):101-104,4.基金项目
It is supported by Medicine and Health Scientific Technological Innovation Project of Fujian Province (2014-CXB-25). 福建省医药卫生科技创新项目(2014-CXB-25) （2014-CXB-25）
