海南医学院学报2018，Vol.24Issue(1)：113-116,120,5.DOI:10.13210/j.cnki.jhmu.20171220.010
丁苯酞对ACI患者血清炎性因子、氧化应激及神经营养因子的影响
Effect of NBP on the serum inflammatory cytokines ,oxidative stress ,and NF in patients with ACI
摘要
Abstract
Objective:To explore the effect of NBP on the serum inflammatory cytokines ,oxidative stress ,and NF in patients with acute cerebral infarction (ACI) .Methods:A total of 118 patients with ACI who were admitted in our hospital from October ,2016 to September ,2017 were included in the study and randomized into the observation group and the control group with 59 cases in each group .The patients in the control group were given blood pressure control ,blood sugar control , micro-circulation improvement ,anti-platelet aggregation ,nerve nourishing ,and lipid regulation .On the above basis ,the pa-tients in the observation group were given intravenous injection of NBP sodium chloride injection .The patients in the two groups were treated for 14d .The morning fasting venous blood before treatment ,7d and 14d after treatment in the two groups was collected ,and centrifuged for the serum .IL-6 ,TFN-α,hs-CRP ,SOD ,MDA ,NSE ,VEGF ,BDNF ,and bFGF .Results:The serum IL-6 ,TFN-α,and hs-CRP 7d and 14d after treatment in the observation group were significantly lower than those in the control group (P<00.5 or P<00.1) .The serum SOD 7d and 14d after treatment in the observation group was signifi-cantly higher than that in the control group ,while MDA was significantly lower than that in the control group (P<00.1) .The serum NSE 7d and 14d after treatment in the observation group was significantly lower than that in the control group ,while VEGF ,BDNF ,and bFGF were significantly higher than those in the control group (P<00.5 or P<00.1) .Conclusions:BNP in the treatment of ACI can down regulate the expression of inflammatory cytokines to play an anti-inflammatory effect ,in-crease the antioxidant ability to remove OFR ,improve the neurocyte metabolism ,and effectively play the nerve protecting and prognosis improvement role .关键词
丁苯酞/急性脑梗死/炎性因子/氧化应激/神经营养因子Key words
BNP/ACI/inflammatory cytokine/oxidative stress/BDNF分类
医药卫生引用本文复制引用
李瑞琳,郭一尘..丁苯酞对ACI患者血清炎性因子、氧化应激及神经营养因子的影响[J].海南医学院学报,2018,24(1):113-116,120,5.基金项目
Gansu science and technology project (2016203) 甘肃省科技计划项目(2016203) （2016203）
