海南医学院学报2018，Vol.24Issue(1)：121-124,4.DOI:10.13210/j.cnki.jhmu.20171222.004
急性脑梗死患者同型半胱氨酸、超敏C反应蛋白与凝血功能检测及意义
Detection and significance of homocysteine ,hypersensitivity C reactive protein and coagu-lation function in patients with acute cerebral infarction
摘要
Abstract
Objective:To explore the changes and significance of homocysteine (Hcy) ,high sensitivity C reactive pro-tein (hs-CRP) and coagulation function indexes in patients with acute cerebral infarction .Methods:A total of 110 patients with acute cerebral infarction were selected as the observation group ,According to the symptoms of acute cerebral infarction to 96 h ,whether the symptoms of neurological deficit were aggravated ,the patients in the observation group could be divided into the progressive group (n=65 case) and the non progressive group (n=45 case) ,and 110 cases of healthy physical examination were selected as control group at the same time .The levels of blood lipid metabolism ,Hcy ,hs-CRP and blood coagulation function were compared in each group .Results:Single factor analysis showed that there was a statistically significant difference in blood lipid metabolism ,Hcy ,hs-CRP and coagulation function between groups (P<00.5) .Compared with the index level in the control group ,the levels of TG ,TC ,LDL ,Hcy ,hs-CRP ,D-dime and FIB in the observation group were significantly higher than those in the control group ,and the HDL level was significantly decreased ,the difference was statistically signifi-cant (P<00.5) .The levels of TG ,TC ,LDL ,Hcy ,hs-CRP ,D-dime and FIB in the progression group were significantly high-er than those in the non progressive group ,HDL level was significantly lower than that in the non progressive group ,with sig-nificant difference (P<00.5) .Correlation analysis showed that the severity of acute cerebral infarction was positively correlated with the levels of TG ,TC ,LDL ,Hcy ,hs-CRP ,D-dime and FIB (r=05.36 ,07.80 ,06.97 ,03.90 ,06.36 ,04.29 ,04.82 ,P<00.5) ,and negatively correlated with HDL level (r= -02.41 , P<00.5) .Conclusion:There are abnormalities of blood lipid metabolism and coagulation function in patients with acute cerebral infarction ,and the levels of Hcy and hs-CRP increase sig-nificantly .Detection of all indexes is of great significance for evaluating the severity of acute cerebral infarction .关键词
急性脑梗死/Hcy/hs-CRP/凝血功能Key words
Acute cerebral infarction/Hcy/hs-CRP/Coagulation function分类
医药卫生引用本文复制引用
陈明,高华,孔祥锋,裴静,牛会娟,刘敬,朱志华..急性脑梗死患者同型半胱氨酸、超敏C反应蛋白与凝血功能检测及意义[J].海南医学院学报,2018,24(1):121-124,4.基金项目
This study was supported by Natural Science Foundation of Xinjiang Uygur Autonomous Region (2016E02C127). 新疆维吾尔自治区自然科学基金 (2016E02C127) （2016E02C127）
