海南医学院学报2018，Vol.24Issue(1)：141-144,4.DOI:10.13210/j.cnki.jhmu.20171128.003
拉莫三嗪+丙戊酸钠联合治疗对难治性癫痫患者神经细胞营养状态及凋亡状态、炎症反应的影响
Effects of lamotrigine + sodium valproate therapy on the nerve cell nutrition and apoptosis status as well as inflammatory response in patients with intractable epilepsy
摘要
Abstract
Objective:To investigate the effects of lamotrigine + sodium valproate therapy on the nerve cell nutrition and apoptosis as well as inflammatory response in patients with intractable epilepsy. Methods:70 patients with intractable epi-lepsy who were treated in our hospital between August 2013 and October 2016 were divided into routine group (n=35) and study group (n=35) by random number table method ,routine group received sodium valproate therapy and study group re-ceived lamotrigine combined with sodium valproate therapy. The differences in serum levels of neurotrophy indexes ,nerve ap-optosis indexes and inflammatory factors were compared between the two groups before and after treatment. Results:Before treatment ,there was no statistically significant difference in serum levels of neurotrophy indexes ,nerve apoptosis indexes and inflammatory factors between the two groups. After treatment ,serum BDNF and NGF levels of study group were higher than those of routine group ;serum Bcl-2 ,Fas and FasL levels of study group were lower than those of routine group whereas Bax level was higher than that of routine group ;serum IL-1β,IL-6 and PGE2 levels of study group were lower than those of routine group. Conclusion:Lamotrigine combined with sodium valproate therapy can effectively increase the neurotrophy ,inhibit the nerve apoptosis and reduce the systemic inflammatory response in patients with intractable epilepsy.关键词
难治性癫痫/拉莫三嗪/丙戊酸钠/神经营养/凋亡/炎症反应Key words
intractable epilepsy/lamotrigine/sodium valproate/neurotrophy/apoptosis/inflammatory response分类
医药卫生引用本文复制引用
唐文,杨梅媚,唐亚宁..拉莫三嗪+丙戊酸钠联合治疗对难治性癫痫患者神经细胞营养状态及凋亡状态、炎症反应的影响[J].海南医学院学报,2018,24(1):141-144,4.基金项目
This study was supported by Medical Research Youth Innovation Subject of Sichuan Province ( Grant No. Q14015) 四川省医学科研青年创新项目(Q14015) （ Grant No. Q14015）
