化工学报2018，Vol.69Issue(1)：259-271,13.DOI:10.11949/j.issn.0438-1157.20170964
天然烟酰胺辅因子再生体系及其人工类似物研究进展
Advances in regeneration system of natural nicotinamide cofactor and its artificial analogues
摘要
Abstract
Oxidoreductases have drawn considerable attention as mild and efficient catalysts in the fields of organic synthesis and medical sciences due to they can catalyze regio-, chemo- and stereoselective transformations that cannot be easily achieved by chemical catalysts.Cofactors are required in oxidoreductase-catalyzed reactions, commonly in the form of nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate, abbreviated as NAD(H) and NADP(H).Given the high cost and physical instability of NAD(H)/NADP(H), the stoichiometric usage is not practical for industrial applications.After decades, four main strategies such as enzymatic, chemical, electrochemical and photochemical method have been used for the cofactor regeneration.Meanwhile, the development of stable, highly active and inexpensive artificial nicotinamide cofactors particularly 1,4-dihydropyridine derivatives has led to a new breakthrough.关键词
生物催化/酶/烟酰胺辅因子/电化学/光化学/人工辅因子Key words
biocatalysis/enzyme/nicotinamide cofactor/electrochemistry/photochemistry/artificial cofactor分类
化学化工引用本文复制引用
朱晨杰,付静雯,谭卓涛,应汉杰..天然烟酰胺辅因子再生体系及其人工类似物研究进展[J].化工学报,2018,69(1):259-271,13.基金项目
国家自然科学基金项目(21776132,21406110,21390204) （21776132,21406110,21390204）
江苏省自然科学基金项目(BK20140938) （BK20140938）
"青年人才托举工程"项目. supported by the National Natural Science Foundation of China (21776132,21406110,21390204),Jiangsu Province Natural Science Foundation for Youths (BK20140938) and Young Elite Scientist Sponsorship Program by CAST. （21776132,21406110,21390204）
